口腔鳞状细胞癌风险因素分析及预测  

Relationship Between Oral Hygiene Status,Chronic Diseases and Oral Squamous Cell Carcinoma and Construction of Nomogram Model for Risk Prediction

作　　者：陶冶[1] 徐培[1] 倪成励[1] 陈国庆 赵丽[2] TAO Ye;XU Pei;NI Chengli;CHEN Guoqing;ZHAO Li(School of Stomatology,Anhui Medical College(Affiliated Stomatological Hospital);The First Affiliated Hospital of Anhui Medical University,Hefei 230601 China)

机构地区：[1]安徽医学高等专科学校口腔医学院(附属口腔医院) [2]安徽医科大学第一附属医院,安徽合肥230601

出　　处：《锦州医科大学学报》2025年第1期92-98,共7页Journal of Jinzhou Medical University

基　　金：安徽省高校优秀青年人才支持项目一般项目,项目编号:gxyq2022192;安徽省高校自然科学研究一般项目,项目编号:ZR2024B005;安徽省高等学校质量工程项目,项目编号:2023kcsz03。

摘　　要：目的探讨口腔卫生状况及慢性病与口腔鳞状细胞癌的关系。方法选择2014年5月至2023年8月于安徽医科大学第一附属医院收治的160例口腔鳞状细胞癌患者作为研究对象,选择同期来安徽医科大学第一附属医院体检的健康者200例为对照组,收集研究对象的既往疾病史、肿瘤家族史、饮食习惯、口腔卫生、饮茶史和吸烟史等,采用非条件Logistic回归模型对口腔鳞状细胞癌发病风险和慢性病、口腔卫生习惯的相关性进行分析,根据性别、饮酒状况和吸烟状况进行分层,且对高血压、复发性口腔溃疡和不良修复体与口腔鳞状细胞癌之间的关系进行分析。结果两组患者的年龄、性别、民族、BMI、婚姻状况、肿瘤家族史、糖尿病家族史、高血脂家族史、糖尿病、高血脂相对比,差异无统计学意义(P>0.05)。研究组文化程度、职业、居住地、高血压家族史、不良修复体、目前牙齿数(颗)、刷牙频率、看牙周期、复发性口腔溃疡、高血压、吸烟、饮酒对比,差异有统计学意义(P<0.05)。Logistic回归分析显示,每次口腔检查周期不低于5年、每日刷牙频率超过1次为保护因素;复发性口腔溃疡、不良修复体和当前牙齿颗数少于20颗或20~27颗、高血压、吸烟、饮酒是危险因素,差异有统计学意义(P<0.05)。在Logistic回归分析中,发现发现口腔鳞状细胞癌的保护因素为每次看牙医周期不低于5年、刷牙频率超过1次/日;而危险因素则包括复发性口腔溃疡、不良修复体以及当前牙齿颗数少于20颗或20~27颗。经分层分析,发现复发性口腔溃疡能够使非饮酒者和非吸烟者的口腔鳞状细胞癌发生风险增加。在非饮酒和非吸烟者中,高血压能够使OSCC的发病风险升高;而在女性人群中,合并高血压者的OSCC风险较高,差异有统计学意义(P<0.05)。结论口腔卫生状况和慢性疾病与OSCC发病之间存在明显关联。不良修复Objective To explore the oral hygiene status and the relationship between chronic diseases and oral squamous cell carcinoma.Methods 160 patients with oral squamous cell carcinoma admitted to the First Affiliated Hospital of Anhui Medical University from May 2014 to August 2023 were selected as the research object,and 200 healthy people who came to the First Affiliated Hospital of Anhui Medical University for physical examination in the same period were selected as the control group.The past disease history,tumor family history,eating habits,oral hygiene,tea drinking history and smoking history of the research object were collected by using the unified questionnaire.Then the unconditional Logistic regression model was used to analyze the correlation between the risk of oral squamous cell carcinoma and chronic diseases and oral hygiene habits,stratified according to gender,drinking status and smoking status,and analyzed the relationship between hypertension,recurrent oral ulcers and poor prostheses and oral squamous cell carcinoma.Results There was no difference in age,sex,nationality,BMI,marital status,family history of tumor,diabetes,hyperlipidemia,diabetes and hyperlipidemia between the two groups(P>0.05).There were differences in education level,occupation,residence,family history of hypertension,bad restorations,current number of teeth,frequency of brushing,dental cycle,recurrent oral ulcer,hypertension,smoking and drinking in the study group(P<0.05).Logistic regression analysis showed that the period of visiting dentists≥5 years/time and the frequency of brushing teeth>1 time/d were the protective factors;recurrent oral ulcer,bad restorations,current number of teeth<20 or 20-27,hypertension,smoking and drinking were risk factors(P<0.05).In Logistic regression analysis,it was found that the protective factors of oral squamous cell carcinoma were≥5 years/visit to the dentist and>1 brushing frequency/d;the risk factors included recurrent oral ulcers,poor restorations and the current number of teeth<20 or 20-

关 键 词：慢性病 口腔卫生 口腔鳞状细胞癌 

分 类 号：R739.8[医药卫生—肿瘤]