核黄素—紫外线A胶原交联术交联效果的可控及可预测性的实验技术及理论研究进展  

Controllability and predictability of riboflavin-ultraviolet A collagen cross-linking:advances in experimental techniques and theoretical research

作　　者：刘晓娜 李晓娜(综述)[1] 陈维毅(审校)[1] LIU Xiaona;LI Xiaona;CHEN Weiyi(Collage of Artificial Intelligence,Taiyuan University of Technology,Taiyuan 030024,P.R.China)

机构地区：[1]太原理工大学人工智能学院,太原030024

出　　处：《生物医学工程学杂志》2025年第1期212-218,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(12172243,U24A20708,12072218);山西省医学重点科研项目(2023XM017);山西省自然科学基金项目(20210302123150,20210302123096)。

摘　　要：核黄素—紫外线A胶原交联术不仅在治疗扩张性角膜病、大疱性角膜病、感染性角膜病等一系列角膜疾病,以及辅助角膜屈光手术治疗中已取得很好的临床疗效,在巩膜交联中的有效性及安全性也已得到初步证实。为了更好地推进交联术在角巩膜疾病临床治疗中的应用,探究手术效果的可控性和可预测性对手术疗效的评估及个性化精准治疗均具有重要意义。本文就核黄素—紫外线A胶原交联的交联深度及其与交联效果之间的关系研究进展进行综述,为进一步推进该术式在眼科临床的应用提供参考。Riboflavin-ultraviolet A(UVA)collagen cross-linking has not only achieved good clinical efficacy in the treatment of corneal diseases such as dilatation keratopathy,bullae keratopathy,infectious keratopathy,and in the combined treatment of corneal refractive surgeries,but also its efficacy and safety in scleral collagen cross-linking have been initially confirmed.To better promote the application of cross-linking in the clinical treatment of corneal and scleral diseases,exploring controllability and predictability of the surgical efficacy are both important for evaluating the surgical efficacy and personalized precision treatment.In this paper,the progress on the cross-linking depth of riboflavin-UVA collagen cross-linking,and its relationship with the cross-linking effect will be reviewed.It will provide the reference for further application of this procedure in ophthalmology clinics.

关 键 词：核黄素—紫外线A胶原交联术 交联深度 交联效果 可控性 

分 类 号：R779.6[医药卫生—眼科]