利培酮片联合重复经颅磁刺激治疗儿童抽动障碍的临床疗效  

Clinical efficacy of risperidone tablets combined with repetitive transcranial magnetic stimulation in the treatment of tic disorder in children

作　　者：罗叶 刘雪琴 张萍萍 蔡文婷 胡春华 温琪凤 LUO Ye;LIU Xueqin;ZHANG Pingping;CAI Wenting;HU Chunhua;WEN Qifeng(Ganzhou Third People's Hospital,Ganzhou,Jiangxi,341000,China)

机构地区：[1]赣州市第三人民医院,江西赣州341000

出　　处：《当代医学》2024年第24期144-147,共4页Contemporary Medicine

基　　金：江西省赣州市指导性科技计划项目(GZ2021ZSF254)。

摘　　要：目的探讨利培酮片联合重复经颅磁刺激治疗儿童抽动障碍临床疗效。方法选取2021年2月至2022年2月赣州市第三人民医院收治的60例儿童抽动障碍患儿作为研究对象,按照随机数字表法分为观察组与对照组,每组30例。对照组予以利培酮片治疗,观察组予以口服利培酮片联合重复经颅磁刺激治疗,比较两组抽动严重程度[耶鲁综合抽动严重程度量表(Yale global tie severityb scale,YGTSS)]、临床有效率及不良反应发生情况。结果治疗后3、6、8周,两组YGTSS评分均低于前一时间点,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后3、6、8周,观察组临床有效率均高于对照组,差异有统计学意义(P<0.05)、观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论利培酮片联合重复经颅磁刺激治疗儿童抽动障碍能改善患儿抽动严重程度,提高临床疗效,减少不良反应,安全性高,值得推广应用。Objective To investigate the clinical efficacy of risperidone tablets combined with repetitive transcranial magnetic stimulation in the treatment of tic disorder in children.Methods 60 children with tic disorder admitted to Ganzhou Third People's Hospital from February 2021 to February 2022 were selected as the research subjects,they were divided into the observation group and the control group according to the random number table method,with 30 cases in each group.The control group was treated with risperidone tablets,and the observation group was treated with oral risperidone tablets combined with repetitive transcranial magnetic stimulation.The tic severity(Yale global tie severityb scale[YGTSS]),clinical efficiency and adverse reactions were compared between the two groups.Results At 3,6 and 8 weeks after treatment,the YGTSS scores of the two groups were lower than those at the previous time point,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).At 3,6 and 8 weeks after treatment,the clinical effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Risperidone tablets combined with repetitive transcranial magnetic stimulation in the treatment of tic disorder in children can improve the severity of tic disorder,improve clinical efficacy,reduce adverse reactions,and have high safety,which is worthy of popularization and application.

关 键 词：利培酮片 重复经颅磁刺激 抽动严重程度 不良反应 

分 类 号：R74[医药卫生—神经病学与精神病学]