腹腔镜结肠癌根治术与开腹手术治疗老年结肠癌的效果观察  

Observation on Effect of Laparoscopic Radical Resection of Colon Cancer and Laparotomy in Treatment of Senile Colon Cancer

作　　者：王伟伟 王磊 管艳花 WANG Wei-wei;WANG Lei;GUAN Yan-hua(Zhengzhou Ninth People's Hospital,Zhengzhou,Henan 450053)

机构地区：[1]郑州市第九人民医院,河南郑州450053

出　　处：《中国肛肠病杂志》2025年第1期16-19,共4页Chinese Journal of Coloproctology

摘　　要：目的:观察腹腔镜结肠癌根治术与开腹手术治疗老年结肠癌的效果。方法:将68例老年结肠癌患者随机分为传统组和干预组,每组34例。传统组患者采用开腹结肠癌根治术治疗,干预组患者采用腹腔镜结肠癌根治术治疗,比较2组患者手术相关指标、炎症因子与免疫指标以及术后并发症发生情况等。结果:干预组患者手术时间、胃肠功能恢复时间、住院时间均短于传统组(P<0.05),术中出血量少于传统组(P<0.05)。治疗前,2组患者炎症因子与免疫指标比较差异无统计学意义(P>0.05);术后2组患者C反应蛋白水平均高于治疗前,白介素-6、CD4^(+)、CD8^(+)水平均低于治疗前,但干预组患者C反应蛋白、白介素-6水平均低于传统组(P<0.05),CD4^(+)、CD8^(+)水平均高于传统组(P<0.05)。干预组患者术后并发症发生率低于传统组(P<0.05)。2组患者生存率、复发率比较差异无统计学意义(P>0.05)。结论:腹腔镜结肠癌根治术与开腹结肠癌根治术对老年结肠癌均有一定治疗效果,但前者方案优势性更强,在保障安全性的同时能提高患者免疫功能,更符合临床治疗要求。Objective To observe the effect of laparoscopic radical resection of colon cancer and laparotomy in the treatment of senile colon cancer.Methods A total of 68 elderly patients with colon cancer were randomly divided into the traditional group and the intervention group,34 cases in each group.Patients in the traditional group were treated with laparotomy for colon cancer,and patients in the intervention group were given laparoscopic radical resection of colon cancer.The operation-related indicators,inflammatory factors,immune indicators,and postoperative complications were compared between the two groups.Results Compared with the traditional group,the intervention group had shorter operation time,gastrointestinal function recovery time,and length of hospital stay(P<0.05)and less intraoperative blood loss(P<0.05).Before treatment,there were no significant differences in inflammatory factors and immune indicators between the two groups(P>0.05).After treatment,the levels of C-reactive protein(CRP)in both groups were higher than those before treatment,and the levels of interleukin-6(IL-6),CD4^(+)and CD8^(+)were lower than those before treatment,but the levels of CRP and IL-6 in the intervention group were lower than those in the traditional group(P<0.05),and the levels of CD4^(+)and CD8^(+)were higher than those in the traditional group(P<0.05).The incidence of postoperative complications in the intervention group was lower than that in the traditional group(P<0.05).There was no significant difference in survival rate and recurrence rate between the two groups(P>0.05).Conclusion Both laparoscopic radical resection of colon cancer and laparotomy for colon cancer have certain therapeutic effect on elderly patients with colon cancer,but the former scheme has more advantages.It can improve the immune function of patients while ensuring safety,and is more in line with the requirements of clinical treatment.

关 键 词：结肠癌 老年 腹腔镜 手术 效果观察 

分 类 号：R735.35[医药卫生—肿瘤]