2型糖尿病合并桥本甲状腺炎患者血清巨噬细胞炎症蛋白-1α、程序性死亡因子-1检测及预测价值  

Changes and predictive value of serum MIP-1αand PD-1 levels in patients with type 2 diabetes mellitus complicated with Hashimoto’s thyroiditis

作　　者：李璟 李雯婷 熊耀翼 沈轩宇 LI Jing;LI Wenting;XIONG Yaoyi;SHEN Xuanyu(Department of Clinical Laboratory,the Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610031,China;Department of Endocrinology,the Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610031,China;Department of Clinical Laboratory,the Fourth People’s Hospital of Sichuan Province,Chengdu 610011,China;Department of Clinical Laboratory,Sichuan Hospital of Integrated Traditional Chinese and Western Medicine,Chengdu 610041,China)

机构地区：[1]成都中医药大学第三附属医院检验科,四川成都610031 [2]成都中医药大学第三附属医院内分泌科,四川成都610031 [3]四川省第四人民医院检验科,四川成都610011 [4]四川省中西医结合医院检验科,四川成都610041

出　　处：《陕西医学杂志》2025年第3期389-393,共5页Shaanxi Medical Journal

基　　金：四川省卫生健康科研课题(19PJ056)。

摘　　要：目的:检测2型糖尿病(T2DM)合并桥本甲状腺炎(HT)患者血清巨噬细胞炎症蛋白-1α(MIP-1α)和程序性死亡因子-1(PD-1)水平,并分析它们对T2DM合并HT的预测价值。方法:选取T2DM合并HT患者46例为研究组,选取同期单纯T2DM患者53例为糖尿病组,选取体检健康者42例为对照组。比较血清MIP-1α、PD-1水平及甲状腺功能相关指标;Pearson法分析血清MIP-1α、PD-1与甲状腺功能相关指标的相关性;Logistic回归分析T2DM合并HT的影响因素;受试者工作特征(ROC)曲线分析血清MIP-1α、PD-1对T2DM合并HT的预测价值。结果:糖尿病组和研究组血清MIP-1α、PD-1水平较对照组升高,且研究组血清MIP-1α、PD-1水平较糖尿病组升高(均P<0.05)。两组糖化血红蛋白(HbA1c)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺球蛋白抗体(ATG-Ab)、甲状腺过氧化物酶抗体(TPO-Ab)水平比较差异有统计学意义(均P<0.05)。MIP-1α和PD-1与TSH、ATG-Ab、TPO-Ab水平均呈正相关,与FT3、FT4水平呈负相关(均P<0.05)。TSH、TPO-Ab、MIP-1α和PD-1为T2DM合并HT的危险因素(均P<0.05)。MIP-1α、PD-1联合预测T2DM合并HT的曲线下面积(AUC)高于MIP-1α、PD-1单独预测(均P<0.05)。结论:T2DM合并HT患者血清MIP-1α、PD-1水平升高,两项联合对T2DM合并HT具有良好的预测价值。Objective:To detect the levels of serum macrophage inflammatory protein-1α(MIP-1α)and programmed death-1(PD-1)in patients with type 2 diabetes mellitus(T2DM)complicated with Hashimoto's thyroiditis(HT),and to analyze their predictive value for T2DM complicated with HT.Methods:A total of 46 patients with T2DM complicated with HT were selected as the study group,53 patients with T2DM alone were selected as the diabetes group,and 42 healthy people were selected as the control group.Serum MIP-1αand PD-1 levels and thyroid function related indicators were compared.Pearson method was used to analyze the correlation between serum MIP-1α,PD-1 and thyroid function related indicators.Logistic regression was used to analyze the influencing factors of T2DM complicated with HT.ROC curve was used to analyze the predictive value of serum MIP-1αand PD-1 for T2DM complicated with HT.Results:Compared with the control group,the serum levels of MIP-1αand PD-1 in the diabetes group and the study group were obviously higher,and the serum levels of MIP-1αand PD-1 in the study group were obviously higher than those in the diabetes group(all P<0.05).The levels of HbA1c,TSH,FT3,FT4,ATG-Ab and TPO-Ab in the diabetes group and the study group were statistically different(all P<0.05).MIP-1αand PD-1 were positively correlated with TSH,ATG-Ab and TPO-Ab levels,and negatively correlated with FT3 and FT4 levels(all P<0.05).TSH,TPO-Ab,MIP-1αand PD-1 were risk factors for T2DM complicated with HT(all P<0.05).The AUC of MIP-1αand PD-1 combined in predicting T2DM complicated with HT was higher than that of MIP-1αor PD-1 alone(all P<0.05).Conclusion:The serum levels of MIP-1αand PD-1 are increased in T2DM patients with HT,and the combination of the two has a good predictive value for T2DM complicated with HT.

关 键 词：2型糖尿病 桥本甲状腺炎 巨噬细胞炎症蛋白-1Α 程序性死亡因子-1 危险因素 预测价值 

分 类 号：R578.1[医药卫生—消化系统]