血塞通滴丸联合氯吡格雷治疗中高危短暂性脑缺血发作的效果及对相关炎症指标的影响  

The effect of Xuesaitong dropping pills combined with clopidogrel in the treatment of medium-high risk transient ischemic attack and its influence on related inflammatory markers

作　　者：徐国栋[1] 董晓莉[1] 梁晓辉 马良 Xu Guodong;Dong Xiaoli;Liang Xiaohui;Ma Liang(Department of Neurological Intervention,Hebei General Hospital,Shijiazhuang 050000,China)

机构地区：[1]河北省人民医院神经介入科,石家庄050000

出　　处：《中国医药》2025年第3期424-427,共4页China Medicine

基　　金：河北省医学适用技术跟踪项目计划(GZ2024006)。

摘　　要：目的探讨血塞通滴丸联合氯吡格雷治疗中高危短暂性脑缺血发作的效果及对相关炎症指标的影响。方法选取2021年12月到2023年8月在河北省人民医院接受治疗的中高危短暂性脑缺血发作患者96例,采用随机数字表法将患者分为对照组(48例)和观察组(48例)。对照组采用硫酸氢氯吡格雷片进行治疗,观察组采用血塞通滴丸联合硫酸氢氯吡格雷片进行治疗,2组均连续治疗2周。比较2组的总有效率、ABCD-2评分、血清炎症指标、急性脑梗死发生率和不良反应发生率。结果观察组的总有效率高于对照组[93.8%(45/48)比79.2%(38/48)],差异有统计学意义(P<0.05)。治疗2周后,2组的ABCD-2评分均低于治疗前,且观察组低于对照组[(2.3±1.0)分比(3.2±1.0)分],差异有统计学意义(P<0.05)。治疗2周后,2组血清白细胞介素1β、单核细胞趋化蛋白1、C反应蛋白水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(均P<0.05)。观察组6个月急性脑梗死发生率低于对照组[4.2%(2/48)比16.7%(8/48)](P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论血塞通滴丸联合氯吡格雷治疗中高危短暂性脑缺血发作可获得较好的效果,可降低ABCD-2评分、血清炎症指标水平以及短期内发生急性脑梗死的风险,且不良反应少而轻微。Objective To investigate the effect of Xuesaitong dropping pills combined with clopidogrel in the treatment of medium-high risk transient ischemic attack and its influence on related inflammatory markers.Methods A total of 96 patients with moderate and high risk transient ischemic attack who were treated in Hebei General Hospital from December 2021 to August 2023 were selected.A total of 96 patients were divided into control group(48 cases)and observation group(48 cases)by random number table method.The control group was treated with clopidogrel bisulfate tablets,and the observation group was treated with Xuesaitong dropping pills combined with clopidogrel bisulfate tablets.Both groups were treated for 2 weeks.The total effective rate,ABCD-2 score,serum inflammatory markers,incidence of acute cerebral infarction,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group[93.8%(45/48)vs 79.2%(38/48)](P<0.05).After 2 weeks of treatment,the ABCD-2 scores of the two groups were lower than those before treatment,and the ABCD-2 score of the observation group was lower than that of the control group[(2.3±1.0)vs(3.2±1.0)](P<0.05).After 2 weeks of treatment,the levels of serum interleukin-1β,monocyte chemoattractant protein-1 and C-reactive protein in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(all P<0.05).The incidence of acute cerebral infarction in the observation group at 6 months was lower than that in the control group[4.2%(2/48)vs 16.7%(8/48)](P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xuesaitong dripping pills combined with clopidogrel in the treatment of medium-high risk transient ischemic attack can achieve good effect,reduce the ABCD-2 score,serum inflammatory index levels and the risk of acute cerebral infarction in the short time,

关 键 词：短暂性脑缺血发作 血塞通滴丸 氯吡格雷 临床效果 急性脑梗死 

分 类 号：R743.31[医药卫生—神经病学与精神病学]