胱抑素C对颅内动脉瘤形成的影响及其他影响动脉瘤破裂出血的危险因素探究  

Influence of Cystatin C on formation of intracranial aneurysm and study on risk factors of aneurysm rupture

作　　者：杨振国 路飞 孙丹 黄冠敏 Yang Zhenguo;Lu Fei;Sun Dan;Huang Guanmin(不详;The First Affiliated Hospital of Anhui University of Science and Technology,Huainan,Anhui 232000,China)

机构地区：[1]安徽理工大学医学院,安徽淮南232000 [2]安徽理工大学第一附属医院,安徽淮南232000

出　　处：《齐齐哈尔医学院学报》2025年第4期344-348,共5页Journal of Qiqihar Medical University

摘　　要：目的 探索血清中高水平的胱抑素C对于颅内动脉瘤形成、发展的影响和影响颅内动脉瘤破裂的危险因素,对于颅内动脉瘤患者的临床治疗和预后评估具有重要意义。方法 回顾性分析2020年1月—2024年5月本院收治的颅内动脉瘤患者226例(动脉瘤组)的临床资料,其中颅内破裂动脉瘤患者186例(破裂组),颅内未破裂动脉瘤患者40例(未破裂组),同时收集100名健康体检者(对照组)的资料。比较各组患者的基本临床信息和实验室指标(血清胱抑素C、尿酸、C反应蛋白),将结果中存在统计学差异的因素纳入到logistic回归模型当中,分析影响颅内动脉瘤破裂出血的影响因素。结果 破裂组与未破裂组在性别、吸烟史、动脉瘤位置方面差异有统计学意义(P<0.05);然而,在年龄、高血压史和糖尿病史方面差异无统计学意义(P>0.05)。Logistic回归分析表明,吸烟史和大小比(尺寸比)(Size ratio, SR)是致使颅内动脉瘤破裂出血的独立危险因素(P<0.05)。另一方面,动脉瘤组血清胱抑素C水平高于对照组,差异有统计学意义(P<0.05)。通过ROC曲线分析,高血清胱抑素C水平可能是动脉瘤形成和发展的危险因素。结论 吸烟和SR是颅内动脉瘤破裂的独立危险因素,血清中高水平的胱抑素C可能是动脉瘤形成的危险因素。破裂组对比未破裂组在血清C反应蛋白、吸烟、性别方面比较有差异,三组在血清尿酸方面比较无差异。Objective To explore the effect of high serum cystatin C on the formation and development of intracranial aneurysms and the risk factors affecting intracranial aneurysm rupture,which is of great significance for the clinical treatment and prognosis evaluation of patients with aneurysms.Methods A retrospective analysis was performed on the clinical data of 226 patients with intracranial aneurysms(aneurysm group)who were admitted to the first affiliated hospital of Anhui University of Science and Technology from January 2020 to May 2024,among them,there were 186 patients with intracranial ruptured aneurysm(ruptured group),40 patients with intracranial unruptured aneurysm(unruptured group),and clinical data of 100 healthy patients(control group)were collected.The basic clinical information and laboratory indicators(Cystatin C,uric acid,C-reactive protein)of each group were compared,and the factors with statistical differences in results were included in the logistic regression model.The influencing factors of intracranial aneurysm rupture were analyzed.Results There were statistically significant differences in gender,smoking history,and aneurysm location between the ruptured group and the non-ruptured group(P<0.05).However,there were no significant differences in age,history of hypertension,and history of diabetes mellitus(P>0.05).Logistic regression analysis showed that smoking history and size ratio(SR)were independent risk factors for intracranial aneurysm rupture and hemorrhage(P<0.05).On the other hand,the serum cystatin C level in the aneurysm group was significantly higher than that in the healthy group(control group),and the difference was statistically significant(P<0.05).Through ROC curve analysis,high serum cystatin C level may be a risk factor for the formation and development of aneurysms.Conclusions Smoking and SR are independent risk factors for intracranial aneurysm rupture,and high level of cystatin C in serum may be risk factors for aneurysm formation.There were differences in serum C-reactive pro

关 键 词：颅内动脉瘤 破裂出血 危险因素 胱抑素C 

分 类 号：R743[医药卫生—神经病学与精神病学]