木醋液“核@壳”复合型微凝珠的制备及其抑菌活性研究  

Preparation of“Core@Shell”composite microcondensation beadsof wood vinegar and its antibacterial activity

作　　者：鲁凯 李浩 刘燕 LU Kai;LI Hao;LIU Yan(College of Life Science and Technology,Tarim University,Alar,Xinjiang 843300)

机构地区：[1]塔里木大学生命科学与技术学院,新疆阿拉尔843300

出　　处：《塔里木大学学报》2025年第1期38-51,共14页Journal of Tarim University

基　　金：塔里木大学校长基金硕士人才项目(TDZKSS202124)。

摘　　要：本研究利用原位凝胶化原理制备了具有核壳交联结构的木醋液复合型微凝珠材料。通过扫描电镜检测,微凝珠材料显示出良好的球形分布,外壳光滑粗糙度低,内部具有明显的三维网状结构,粒度分布良好。傅里叶变换红外光谱和X射线衍射分析证实了交联的成功。体外药物释放和抗菌活性实验结果表明,“核@壳”微凝珠具有靶向效应和抗菌活性。在治疗由肠致病性大肠杆菌诱导的小鼠腹泻模型时,微凝珠不仅表现出良好的抗菌和抗炎特性也具有优秀的生物相容性。In this study,wood vinegar composite microcondensation bead materials with a core-shell cross-linking structure were prepared using the principle of in situ gelation.The microcondensation bead materials were observed under scanning electron microscopy to exhibit a good spherical distribution,a smooth shell with low roughness,and an evident three-dimensional mesh structure with a well-defined particle size distribution.The success of the cross-linking process was confirmed by Fourier transform infrared spectroscopy and X-ray diffraction analysis.The results of the in vitro drug release and antibacterial experiments demonstrated that the“core@shell”microcoagulant beads possessed a targeted effect and antibacterial activity.In the treatment of a mouse diarrhoea model induced by enteropathogenic Escherichia coli,the microcondensation beads exhibited excellent antibacterial and anti-inflammatory properties,as well as excellent biocompatibility.

关 键 词：木醋液 原位凝胶化 抑菌效果 微凝珠 

分 类 号：R914.2[医药卫生—药物化学]