穴位贴敷疗法联合运动处方治疗非酒精性脂肪性肝病患者疗效初步研究  

A preliminary study on acupoint application at base of sport exercise in the treatment of patients with non-alcoholic fatty liver disease

作　　者：钱平安[1] 姜煜资 聂红明[1] Qian Ping’an;Jiang Yuzi;Nie Hongming(Department of Hepatology,Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院肝病科,上海市200071

出　　处：《实用肝脏病杂志》2025年第2期206-209,共4页Journal of Practical Hepatology

基　　金：上海市卫生健康委员会科研项目(编号:202240255)。

摘　　要：目的探讨穴位贴敷疗法联合运动处方治疗非酒精性脂肪性肝病(NAFLD)患者的疗效。方法2022年1月~2024年3月我院诊治的NAFLD患者119例,被分为对照组59例和联合组60例,分别给予运动处方或在运动处方的基础上联合穴位贴敷疗法治疗,均治疗3个月。测量体质量、腰围、体脂率(BFP),计算体质指数(BMI)和腰臀比(WHR)。采用双抗体夹心ELISA法检测血清瘦素、脂联素、抵抗素、肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)。结果在治疗3个月末,联合组体质量、BMI和BFP分别为(62.3±7.8)kg、(24.5±3.3)kg/m 2和(29.2±3.6)%,均显著低于对照组【分别为(68.2±8.9)kg、(26.8±2.8)kg/m 2和(31.7±3.9)%,P<0.05】;血清TG和LDL-C水平分别为(2.1±0.3)mmol/L和(2.3±0.5)mmol/L,均显著低于对照组【分别为(2.9±0.3)mmol/L和(2.8±0.7)mmol/L,P<0.05】,而血清HDL-C水平为(1.3±0.3)mmol/L,显著高于对照组【(1.1±0.3)mmol/L,P<0.05】;血清ALT、AST和GGT水平分别(45.1±8.7)U/L、(41.5±8.0)U/L和(38.7±7.8)U/L,均显著低于对照组【分别为(56.8±7.3)U/L、(52.4±6.6)U/L和(46.2±8.5)U/L,P<0.05】;血清瘦素、抵抗素、TNF-α和IL-6水平分别为(9.7±2.1)pg/mL、(9.8±3.9)ng/mL、(21.2±5.2)ng/L和(20.1±2.3)mg/L,均显著低于对照组【分别为(11.8±2.0)pg/mL、(13.2±4.3)ng/mL、(27.8±4.7)ng/L和(27.5±2.7)mg/L,P<0.05】,而血清脂联素水平为(3.1±1.0)ng/mL,显著高于对照组【(2.5±0.8)ng/mL,P<0.05】。结论采取穴位贴敷疗法联合运动处方治疗NAFLD患者可以收到较好的短期疗效,体质量下降,血脂水平降低,可能与抑制了机体炎性反应有关。Objective The aim of this study was to investigate short-term efficacy of acupoint application at base of sport exercise in the treatment of patients with non-alcoholic fatty liver disease(NAFLD).Methods 119 patients with NAFLD were encountered in our hospital between January 2022 and March 2024,and were randomly divided into control(n=59)and combination group(n=60),receiving sport exercise under guidance or acupoint application at base of sport exercise for 3 months.Weight,waist circumference,and body fat percentage(BFP)were measured,and body mass index(BMI)and waist to hip ratio(WHR)were calculated.Serum leptin,adiponectin,resistin,tumor necrosis factor alpha(TNF-α)and interleukin-6(IL-6)levels were assayed by ELISA.Results By end of 3 months of treatment,body weight,BMI and BFP in combination group were(62.3±7.8)kg,(24.5±3.3)kg/m 2 and(29.2±3.6)%,all significantly lower than[(68.2±8.9)kg,(26.8±2.8)kg/m 2 and(31.7±3.9)%,respectively,P<0.05]in the control;serum TG and LDL-C levels were(2.1±0.3)mmol/L and(2.3±0.5)mmol/L,both significantly lower than[(2.9±0.3)mmol/L and(2.8±0.7)mmol/L,P<0.05],while serum HDL-C level was(1.3±0.3)mmol/L,significantly higher than[(1.1±0.3)mmol/L,P<0.05]in the control group;serum ALT,AST and GGT levels were(45.1±8.7)U/L,(41.5±8.0)U/L and(38.7±7.8)U/L,all much lower than[(56.8±7.3)U/L,(52.4±6.6)U/L and(46.2±8.5)U/L,respectively,P<0.05]in the control;serum leptin,resistin,TNF-αand IL-6 levels were(9.7±2.1)p g/mL,(9.8±3.9)ng/mL,(21.2±5.2)ng/L and(20.1±2.3)mg/L,all much lower than[(11.8±2.0)pg/mL,(13.2±4.3)ng/mL,(27.8±4.7)ng/L and(27.5±2.7)mg/L,respectively,P<0.05],while serum adiponectin level was(3.1±1.0)ng/mL,much higher than[(2.5±0.8)ng/mL,P<0.05]in the control group.Conclusion Acupoint application in combination with exercise in treating patients with NAFLD is short-termly efficacious,with body weight loss and reduced blood fat,which might be related to inhibition of body inflammatory reactions.

关 键 词：非酒精性脂肪性肝病 穴位贴敷 运动处方 治疗 

分 类 号：R575.5[医药卫生—消化系统]