肝性脑病动物模型研究进展  

Animal models of hepatic encephalopathy

作　　者：杨雪梦 尹东豪(综述) 胡建华(审校) Yang Xuemeng;Yin Donghao;Hu Jianhua(Center for Integrative Chinese and Western Medicine,You’an Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院中西医结合中心,北京市100069

出　　处：《实用肝脏病杂志》2025年第2期316-319,共4页Journal of Practical Hepatology

基　　金：北京市扬帆计划重点医学专业-中西医结合重症肝病研究项目(编号:ZYLX201819);中西医结合防治传染病临床与基础研究-中西医专项课题资助项目(编号:BJYY-YN2022-32)。

摘　　要：肝性脑病(HE)是肝脏疾病常见的并发症。由于HE发病机制复杂,通常使用动物模型研究HE发病的病理生理机制,以探讨潜在的治疗策略。随着现代科技的进步,HE动物模型得到了显著的改进和发展。本文结合最新研究成果,综述了HE动物模型的建立、评估、应用、局限性和未来应用前景,旨在为HE的治疗探索新的方法。Hepatic encephalopathy(HE)is a common complications of severe liver disease,with high recurrence rate and hard to deal with.Animal models are frequently employed in research to investigate pathophysiological mechanisms and explore potential therapeutic strategies.With advancements in modern medical technology,animal models for HE research have undergone remarkable improvements.In this review,we reviewed the latest research progress,focusing on establishment,evaluation,application,limitations,and future prospects of animal models in this field,with aiming to explore new therapeutic approaches for HE.

关 键 词：肝性脑病 动物模型 评估 

分 类 号：R73[医药卫生—肿瘤]