环指蛋白183的生物学功能及其在疾病中的作用  

Biological functions of cyclin 183 and its effects in disease

作　　者：杨睿睿(综述) 高诗雨 汪建初[2] 宾晓芸[3] 王长丽(审校) Yang Ruirui;Gao Shiyu;Wang Jianchu;Bin Xiaoyun;Wang Changli(Institute of Life Sciences,Youjiang Medical University for Nationalities,Baise 533000;College of Clinical Medicine,Youjiang Medical University for Nationalities,Baise 533000;College of Basic Medical Sciences,Youjiang Medical University for Nationalities,Baise 533000)

机构地区：[1]右江民族医学院生命科学研究院,百色533000 [2]右江民族医学院临床医学院,百色533000 [3]右江民族医学院基础医学院,百色533000

出　　处：《安徽医科大学学报》2025年第2期366-371,共6页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:82060441);广西自然科学基金(编号:2024GXNSFAA010120);2021年右江民族医学院“新启航”青年骨干项目(编号:DC2200001896);广西壮族自治区级大学生创新创业训练计划项目(编号:S202410599064);右江民族医学院2018年度校级科研课题(编号:RZ2100000376)。

摘　　要：环指蛋白183(RNF183)是一种E3泛素连接酶,它可以催化泛素分子与底物蛋白的共价连接。RNF183在肾脏和睾丸等组织中均有表达,它主要被定位在细胞中的内质网、高尔基体、溶酶体。RNF183作为内质网膜的组成部分之一,参与了内质网应激响应通路影响细胞及蛋白质泛素化。近年来,关于RNF183与结直肠癌、子宫内膜癌和膀胱癌等多种疾病关系的研究逐渐增多。该文对RNF183在结直肠癌、炎症性肠病等疾病中的作用以及内质网应激等生物学功能进行了总结,旨在对相关疾病研究提供参考思路。Ring finger protein 183(RNF183)is an E3 ubiquitin ligase that catalyzes the covalent attachment of ubiquitin molecules to substrate proteins.RNF183 is expressed in tissues such as kidney and testis,and it is mainly localized to the endoplasmic reticulum,Golgi apparatus,and lysosomes in cells.As one of the components of the endoplasmic reticulum membrane,it participates in the endoplasmic reticulum stress-responsive pathway that affects cellular and protein ubiquitination.In recent years,the study of E3 ubiquitin ligase member-RNF183 with various diseases such as colorectal cancer,endometrial cancer and bladder cancer has gradually increased.In this review,the role of RNF183 in colorectal cancer,inflammatory bowel disease and other diseases,as well as biological functions such as endoplasmic reticulum stress are summarized,aiming to provide reference ideas for the study of related diseases.

关 键 词：泛素化修饰 环指蛋白183 内质网应激 结直肠癌 炎症性肠病 膀胱癌 

分 类 号：R730.2[医药卫生—肿瘤]