CT引导射频消融术在早期肺癌患者中的临床应用效果  

Clinical effects of CT-guided radiofrequency ablation in patients with early-stage lung cancer

作　　者：王坤亮 闫进 袁俊华 Wang Kunliang;Yan Jin;Yuan Junhua(Department of Thoracic Surgery,Guangji Cardiovascular Disease Hospital,Zhumadian,Henan 463000,China;不详)

机构地区：[1]驻马店广济心血管病医院胸外科,463000 [2]联勤部保障部队990医院胸外科 [3]驻马店广济心血管病医院放射科,463000

出　　处：《实用医学影像杂志》2025年第1期42-45,共4页Journal of Practical Medical Imaging

摘　　要：目的 分析CT引导射频消融术对早期肺癌的应用效果。方法 选取2022年7月至2023年7月在本院接受诊治的早期肺癌患者98例作为研究对象,依据数字排列表法将其分为对照组(45例)和观察组(53例),对照组患者进行常规诊治,而观察组则进行CT引导射频消融术进行诊治,对2组患者细胞分裂周期相关蛋白5(CDCA5)表达、生存率、复发率、肿瘤标志物[甲胎蛋白(AFP)、癌胚抗原(CEA)]、肿瘤灶直径进行对比观察。结果 治疗前2组患者CDCA5表达差异无统计学意义(P>0.05),治疗后2组CDCA5表达较于治疗前均有所降低,且观察组较对照组更低(P<0.05);对2组患者治疗后进行2年随访发现,观察组患者生存率较于对照组更高,但复发率较对照组更低(P<0.05);治疗前2组患者肿瘤灶直径差异无统计学意义(P>0.05),治疗半年、1年、2年后观察组患者肿瘤灶直径较对照组更小(P<0.05);治疗前2组患者AFP、CEA指标差异无统计学意义(P>0.05),治疗后观察组AFP、CEA指标较于对照组更低(P<0.05)。结论 早期肺癌患者使用CT引导射频消融术诊治能够有效改善患者肿瘤标志物指标及CDCA5表达、提高生存率、降低复发率,对患者康复具有较高临床效果,值得推广应用。Objective To analyze the application effect of CT-guided radiofrequency ablation on early lung cancer.Methods Ninety-eight patients with early-stage lung cancer who received treatment in our hospital from July 2022 to July 2023 were selected as the research subjects and were divided into the control group(n=45)and the observation group(n=53)according to the numerical ranking table method,and the patients in the control group underwent conventional treatment,while the observation group underwent CT-guided radiofrequency ablation,and the patients of the two groups were examined in terms of their CDCA5 expression,survival rate,and recurrence rate,Tumor markers[alpha-fetoprotein(AFP),carcinoma embryonic antigen(CEA)],and the diameter of tumor foci were compared.Results There was no significant difference in the expression of CDCA5 between the two groups before treatment(P>0.05).After treatment,the expression of CDCA5 in the two groups was lower than that before treatment,and the observation group was lower than the control group(P<0.05).After 2 years of follow-up,the survival rate of observation group was higher than control group,but the recurrence rate was lower than control group(P<0.05).There was no significant difference in tumor lesion diameter between the two groups before treatment(P>0.05),and the tumor lesion diameter of the observation group was smaller than that of the control group after six months,one year and two years of treatment(P<0.05).Before treatment,there was no significant difference in the AFP and CEA indexes between the two groups(P>0.05),and after treatment,the AFP and CEA indexes in the observation group were lower than those in the control group(P<0.05).Conclusion CT-guided radiofrequency ablation in early-stage lung cancer patients can effectively improve tumor marker indicators and CDCA5 expression,improve survival rate,reduce recurrence rate,which have a high clinical effect on patients′recovery,and is worthy of application.

关 键 词：体层摄影术 X线计算机 射频消融术 肺肿瘤 肺切除术 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]