血清磷脂酶A2和磷酸甘油酸激酶1水平对老年前列腺癌内分泌治疗的预后评估  

Serum phospholipase A2 and phosphoglycerate kinase 1 levels for prognostic assessment of endocrine therapy in elderly patients with prostate cancer

作　　者：蔡淳杰 张锦[1] CAI Chunjie;ZHANG Jin(Department of Urology,The Affiliated Suzhou Hospital of Nanjing University Medicine School,Suzhou Science and Technology City Hospital,Suzhou,Jiangsu 215153,China)

机构地区：[1]南京大学医学院附属苏州医院苏州科技城医院泌尿外科,江苏苏州215153

出　　处：《中国临床研究》2025年第2期252-256,共5页Chinese Journal of Clinical Research

基　　金：国家自然科学基金青年项目(32300799);苏州高新区医疗卫生科技计划重点项目(2019Z012)。

摘　　要：目的探讨血清磷脂酶A2(PLA2)、磷酸甘油酸激酶1(PGK1)水平在老年前列腺癌患者内分泌治疗中的预后评估价值。方法选取2021年6月到2023年6月苏州科技城医院收治的行内分泌治疗的前列腺癌老年患者106例作为观察组。另取60例体检健康老年人设为对照组,所有研究对象血清PLA2、PGK1水平均采用酶联免疫吸附法(ELISA)测定。使用单因素和多因素logistic回归分析影响内分泌治疗的预后因素。结果观察组患者血清PLA2[(34.75±1.26)ng/mL vs(4.58±1.02)ng/mL,t=158.353,P<0.01]、PGK1[(10.69±0.36)ng/mL vs(1.54±0.07)ng/mL,t=194.561,P<0.01]显著高于对照组。多因素logistic回归分析提示血清PLA2、PGK1水平以及肿瘤的TNM分期是老年前列腺癌患者内分泌治疗效果的独立影响因素(P<0.05)。结论血清PLA2和PGK1水平及肿瘤TNM分期可以预测内分泌治疗的前列腺癌老年患者的预后,具有较高预测价值。Objective To investigate the prognostic assessment value of serum phospholipase A2(PLA2)and phosphoglycerate kinase 1(PGK1)levels in elderly patients with prostate cancer undergoing endocrine therapy.Methods A total of 106 elderly patients with prostate cancer who underwent endocrine therapy at Suzhou Science and Technology City Hospital from June 2021 to June 2023 were selected as the observation group.Additionally,60 healthy elderly individuals undergoing physical examination were set as the control group.Serum levels of PLA2 and PGK1 in all subjects were measured using enzyme-linked immunosorbent assay(ELISA).Univariate and multivariate logistic regression analyses were used to identify factors affecting the prognosis of endocrine therapy.Results Compared with the control group,the observation group had significantly higher serum levels of PLA2[(34.75±1.26)ng/mL vs(4.58±1.02)ng/mL,t=158.353,P<0.01]and PGK1[(10.69±0.36)ng/mL vs(1.54±0.07)ng/mL,t=194.561,P<0.01].Multivariate logistic regression analysis indicated that serum levels of PLA2,PGK1,and TNM staging of the tumor were independent prognostic factors for the efficacy of endocrine therapy in elderly patients with prostate cancer(P<0.05).Conclusion Serum levels of PLA2 and PGK1,along with TNM staging of the tumor,can predict the prognosis of elderly patients with prostate cancer undergoing endocrine therapy and have high predictive value.

关 键 词：前列腺癌 血清磷脂酶A2 血清磷酸甘油酸激酶1 内分泌治疗 TNM分期 预后 

分 类 号：R737.25[医药卫生—肿瘤]