DNA甲基化在抑郁症中的作用  

Roles of DNA methylation on major depressive disorder

作　　者：罗海丽 洪青晓 刘惠芬[2] 禹海航 LUO Haili;HONG Qingxiao;LIU Huifen;YU Haihang(Health Science Center,Ningbo University,Ningbo 315211,China;The Affiliated Kangning Hospital of Ningbo University,Ningbo 315201,China)

机构地区：[1]宁波大学医学部,宁波315211 [2]宁波大学附属康宁医院,宁波315201

出　　处：《生命的化学》2025年第1期8-17,共10页Chemistry of Life

基　　金：浙江省医学重点扶植学科建设项目(00-F06);宁波市医疗卫生高端团队重大攻坚项目(2022030410)。

摘　　要：抑郁症是一种常见并且可能导致严重社会功能损害的精神疾病,其发病机制仍尚未完全阐明,目前缺乏客观的诊断和治疗的生物标志物。表观遗传学是指在DNA序列不发生改变的情况下发生基因表达功能的可遗传变化,其中DNA甲基化是表观遗传修饰的主要形式之一。抑郁症相关基因DNA甲基化在其疾病进展中发挥重要作用,对抑郁症的诊治具有重要意义。本文就DNA甲基化在抑郁症中的研究进展进行综述,以期为抑郁症的研究提供参考。Major depressive disorder is a common mental illness that may lead to severe social dysfunction.Its pathogenesis is still not fully unknown,lacking objective biomarkers for diagnosis and treatment.Epigenetics refers to heritable changes in gene expression that occur without alterations in DNA sequence,with DNA methylation being one of the main forms of epigenetic modification.DNA methylation of major depressive disorder related genes plays an important role in the progression of disease,which has great significance for the diagnosis and treatment of major depressive disorder.This paper reviews the research progress on DNA methylation,in order to provide valuable reference for future research on major depressive disorder.

关 键 词：抑郁症 表观遗传学 DNA甲基化 

分 类 号：R74[医药卫生—神经病学与精神病学]