肿瘤相关成纤维细胞在结直肠癌发生发展中的作用  

The role of tumor-associated fibroblasts in the development of colorectal cancer

作　　者：马一诺 王群[1] 巴微 李鑫[1] 孙诗涵 李婉明[1] MA Yinuo;WANG Qun;BA Wei;LI Xin;SUN Shihan;LI Wanming(Department of Molecular Cell Biology,Key Laboratory of Cell Biology,National Health Commission of the People's Republic of China,Key Laboratory of Medical Cell Biology,Ministry of Education of the People's Republic of China,College of Life Sciences,China Medical University,Shenyang 110122,China)

机构地区：[1]中国医科大学卫生健康委员会细胞生物学重点实验室,医学细胞生物学教育部重点实验室,生命科学学院分子细胞生物学教研室,沈阳110122

出　　处：《生命的化学》2025年第1期104-110,共7页Chemistry of Life

基　　金：国家自然科学基金项目(82373445)。

摘　　要：肿瘤的发生发展不仅与自身携带的基因有关,且与其生存场所——肿瘤微环境密切相关。肿瘤相关成纤维细胞(cancer-associated fibroblasts,CAFs)是肿瘤微环境中最主要的基质细胞,它可以通过分泌各种因子和细胞外基质等方式参与肿瘤的发生发展过程。研究发现,CAFs通过与结直肠癌细胞相互作用,影响结直肠癌细胞增殖、侵袭转移、免疫逃逸和耐药等。本文总结了CAFs的来源及其在结直肠癌的发生发展中影响肿瘤细胞的多个方面,对目前CAFs的研究做了分析归纳,并提出了CAFs可以作为未来肿瘤治疗新靶点的可能性,以期为后续研究提供理论参考。The occurrence and development of tumors are not only related to the genes they carry,but also closely related to their living environment,the tumor microenvironment.Cancer-associated fibroblasts(CAFs)constitute the principal stromal cells within the tumor microenvironment and contribute to tumor development through the secretion of diverse factors and the formation of the extracellular matrix.Many studies have revealed that CAFs engage with colorectal cancer cells,thereby influencing their proliferation,invasion,metastasis,immune evasion,and drug resistance.This paper reviews the origins of CAFs and their multifaceted impact on tumor cells in colorectal carcinogenesis,synthesizes current research on CAFs and raises the prospect of CAFs emerging as novel targets for cancer therapy,aiming to serve as theoretical references for future investigations.

关 键 词：肿瘤相关成纤维细胞 结直肠癌 肿瘤微环境 

分 类 号：R735.34[医药卫生—肿瘤]