三维结构可视化软件ChimeraX的教学改革经验与创新实践  

Teaching experience reform and innovative practice of ChimeraX,a 3D structural visualization software

作　　者：蒋嵩山 谢伟 JIANG Songshan;XIE Wei(Department of Biochemistry,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China)

机构地区：[1]中山大学生命科学学院生物化学系,广州510275

出　　处：《生命的化学》2025年第1期165-171,共7页Chemistry of Life

基　　金：中山大学生命科学学院2024年教学质量与教学改革工程类项目(33000-12220011)。

摘　　要：随着结构生物信息学的快速发展,三维结构可视化软件在教育和科研领域的重要性逐渐凸显。ChimeraX作为一款功能强大的分子可视化软件,因其出色的展示与分析蛋白质三维结构的能力,被广泛应用于结构生物学的教学与研究中。本文旨在分享教师在本科生课程结构生物学实验技能课中ChimeraX软件的教学改革经验,介绍了ChimeraX的常用功能及一般性操作,并探讨了蛋白质三维结构可视化软件在未来科研中的应用前景。同时,本文提出了以学生为中心的互动模式、实践为主、模块化的教学方法,旨在提升学生的学习效果和科研能力。实际教学反馈及评估充分验证了该教学方法的有效性。With the rapid development of structural bioinformatics,the importance of 3D structure visualization software in the field of education and scientific research has become prominent.ChimeraX is a powerful molecular visualization software that is widely used in the teaching and research of structural biology because of its excellent ability to visualize and analyze the three-dimensional structure of proteins.The purpose of this paper is to share the instructors'experience in the teaching reform of ChimeraX software in the undergraduate course Structural Biology Experimental Skills.It introduces the commonly used functions of ChimeraX and demonstrates the practical application of the software.Additionally,the future application prospects of protein three-dimensional structure visualization software in research are discussed.This paper also proposes a student-centered,interactive,practice-oriented,and modular teaching approach,aimed at enhancing students'learning outcomes and research capabilities.Through the analysis of actual teaching cases,the effectiveness of this teaching method is fully validated.

关 键 词：实验技能课 三维结构 结构可视化 可视化软件 教学改革 人工智能 ChimeraX 

分 类 号：G642[文化科学—高等教育学] Q811.4-4[文化科学—教育学]