深部热疗在改善结直肠癌术后辅助化疗副反应及生活质量中的作用研究  

The study on the effects of deep hyperthermia in improving side effects of adjuvant chemotherapy and quality of life in the patients after colorectal cancer surgery

作　　者：赵磊 刘文志[1] 林峰[1] 于剑 孙铭骏 崔佑刚[1] 张旭[1] 衣宇鹏 于宝胜 冯宁[1] Lei Zhao;Wenzhi Liu;Feng Lin;Jian Yu;Mingjun Sun;Yougang Cui;Xu Zhang;Yupeng Yi;Baosheng Yu;Ning Feng(Department of Gastrointestinal Surgery,Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,China;Hyperthermia Center,Affiliated Zhongshan Hospital of Dalian University,Dalian 116001,China)

机构地区：[1]大连大学附属中山医院胃肠外科,116001 [2]大连大学附属中山医院热疗中心,116001

出　　处：《中华结直肠疾病电子杂志》2024年第6期488-493,共6页Chinese Journal of Colorectal Diseases(Electronic Edition)

摘　　要：目的探索热疗对结直肠癌术后辅助化疗患者的骨髓抑制程度、化疗不良反应、生活质量评分等各项指标的影响。方法选取2021年9月30日至2023年12月31日大连大学附属中山医院胃肠外科确诊的52例结直肠癌患者病例资料,根据入院顺序及结合患者意愿,其中试验组29例患者术后接受辅助化疗联合深部热疗,对照组23例患者术后仅接受辅助化疗。两组患者均完成6~8周期XELOX辅助化疗方案。比较两组患者治疗期间的骨髓抑制程度、化疗不良反应及患者生活质量。结果在骨髓抑制方面,试验组血小板(χ^(2)=4.293,P<0.05)和中性粒细胞(χ^(2)=4.629,P<0.05)中重度下降的发生率显著低于对照组,差异有统计学意义。在肝功能损害方面,试验组胆红素(χ^(2)=4.302,P<0.05)和谷丙转氨酶(χ^(2)=7.719,P<0.05)中重度升高的发生率显著低于对照组,差异有统计学意义。在胃肠道反应方面,试验组中重度恶心呕吐的发生率显著低于对照组,差异有统计学意义(χ^(2)=4.476,P<0.05)。在生活质量方面,两组患者治疗后GIQLI评分较治疗前均显著升高,但试验组的评分较对照组升高更为显著,差异有统计学意义(t=15.914,P<0.05)。结论深部热疗能减轻结直肠癌术后辅助化疗患者的血小板降低、中性粒细胞降低、肝功能损害及恶心呕吐等化疗副反应,能改善患者的生活质量。Objective To explore the effects of hyperthermia on myelosuppression,chemotherapy adverse reactions and quality of life scores in patients with adjuvant chemotherapy after colorectal cancer surgery.Methods According to the admission order and patient preference,fifty-two patients who had been diagnosed with colorectal cancer and accepted radical surgery in Department of Gastrointestinal Surgery,Affiliated Zhongshan Hospital of Dalian University from September 30,2021 to December 31,2023,were selected for our research.Among them,twenty-nine patients who had accepted postoperative adjuvant chemotherapy combined with deep hyperthermia were grouped into the experimental group,and the left 23 patients who had accepted the postoperative adjuvant chemotherapy only were grouped into the control group.The adjuvant chemotherapeutic regimen of both groups was XELOX regimen.The effects of deep hyperthermia on the adverse reactions after chemotherapy were explored by analyzing and comparing the occurrence of myelosuppression,adverse reactions and quality of life during treatment in the experimental group and the control group.Results In terms of myelosuppression,the incidence of moderate and severe platelet decline in experimental group was significantly lower than that in control group,the difference is significant(χ^(2)=4.293,P<0.05).The incidence of moderate and severe neutrophil decline in experimental group was significantly lower than that in control group,the difference is significant(χ^(2)=4.629,P<0.05).The incidence of moderate and severe elevation of bilirubin in experimental group was significantly lower than that in control group,the difference is significant(χ^(2)=4.302,P<0.05).The incidence of moderate and severe elevation of alanine aminotransferase in experimental groups was significantly lower than that in control group,the difference is significant(χ^(2)=7.719,P<0.05).In respect of the side effects of nausea and vomiting,the incidence of moderate to severe nausea and vomiting in experimental group was si

关 键 词：结直肠肿瘤 热疗 辅助化疗 不良反应 生活质量 

分 类 号：R73[医药卫生—肿瘤]