ICAM-1基因多态性与结肠息肉复发的临床关系分析  

Clinical relationship between ICAM-1 gene polymorphism and colonic polyps recurrence

作　　者：周涛 王益民[1] 徐红梅[2] ZHOU Tao;WANG Yimin;XU Hongmei(General Surgery Second Ward,the First Hospital of Qinhuangdao,Qinhuangdao 066000,China;Department of Oncology,the First Hospital of Qinhuangdao,Qinhuangdao 066000,China)

机构地区：[1]秦皇岛市第一医院普通外科二病区,河北秦皇岛066000 [2]秦皇岛市第一医院肿瘤科,河北秦皇岛066000

出　　处：《东南大学学报(医学版)》2025年第1期133-138,共6页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:分析细胞间黏附分子-1(ICAM-1)基因多态性与结肠息肉复发的临床关系。方法:选取2021年1月至2022年8月本院收治的159例行内镜手术的结肠息肉患者,聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测患者静脉血ICAM-1基因多态性。随访1年,根据是否复发将患者分为复发组和未复发组,比较两组患者的一般资料及ICAM-1基因多态性。Logistic回归分析探讨结肠息肉患者复发的影响因素。结果:ICAM-1基因K469E多态性位点包含有2种等位基因(K、E)和3种基因型(KK、KE、EE)。随访期间,结肠息肉复发率为18.24%。复发组患者息肉直径、多发息肉占比、腺瘤性息肉占比、ICAM-1基因K等位基因频率和KK基因型占比高于未复发组(P<0.05),ICAM-1基因E等位基因频率和EE基因型占比低于未复发组(P<0.05)。多因素Logistic回归分析结果显示,息肉直径(OR=1.692,95%CI:1.304~2.196)、多发息肉(OR=1.647,95%CI:1.128~2.204)、腺瘤性息肉(OR=1.464,95%CI:1.108~1.933)、ICAM-1基因型KK(OR=1.887,95%CI:1.265~2.815)均是结肠息肉复发的影响因素(均P<0.05)。结论:结肠息肉复发患者ICAM-1基因K等位基因频率和KK基因型占比高于未复发患者,ICAM-1基因多态性是结肠息肉患者术后复发的影响因素,对结肠息肉复发有潜在的临床预测价值。Objective:To analyze the clinical relationship between intercellular adhesion molecule-1(ICAM-1)gene polymorphism and colon polyp recurrence.Method:A total of 159 patients with colon polyps undergoing endoscopic surgery admitted to our unit from January 2021 to August 2022 were enrolled as the study objects,and the polymorphism of ICAM-1 gene was detected by polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP)technology.After 1 year of follow-up,patients were divided into recurrence group and non-recurrence group according to whether they had relapsed or not.The general information and ICAM-1 gene polymorphism of the two groups were compared.Logistic regression analysis was used to investigate the factors affecting the recurrence of colon polyps.Results:ICAM-1 gene K469E polymorphic loci contained 2 alleles(K,E)and 3 genotypes(KK,KE,EE).During the follow-up period,the recurrence rate of colon polyps was 18.24%.The polyp diameter,proportion of multiple polyps,proportion of adenomatous polyps,frequency of ICAM-1 gene K allele and proportion of KK genotype in the recurrent group were higher than those in the non-recurrent group(P<0.05).The E allele frequency and EE genotype proportion of ICAM-1 gene were lower than those of non-relapsed group(P<0.05).Polyp diameter(OR=1.692,95%CI:1.304-2.196),multiple polyps(OR=1.647,95%CI:1.128-2.204),adenomatous polyps(OR=1.464,95%CI:1.108-1.933)and ICAM-1 genotype KK(OR=1.887,95%CI:1.265-2.815)were the risk factors for postoperative recurrence in patients with colon polyps(P<0.05).Conclusion:The frequency of ICAM-1 gene K allele and the proportion of KK genotype in patients with recurrent colon polyps are higher than those in the non-recurrent group.ICAM-1 gene polymorphism,an influencing factor for postoperative recurrence in colon polyp patients,has potential clinical predictive value for colon polyp recurrence.

关 键 词：细胞间黏附分子-1 基因多态性 结肠息肉 复发 

分 类 号：R574.62[医药卫生—消化系统]