IL-7R在泛癌中的预后和免疫学作用  

Prognostic and immunological role of IL-7R in pan-cancer

作　　者：张迎锦 邝玉慧 张晓彤 赵强 杨芳明[1] 张传雷[1] 王新亭[1] 袁长威 陈晓琦[1] 陈欣菊[1] ZHANG Yingjin;KUANG Yuhui;ZHANG Xiaotong;ZHAO Qiang;YANG Fangming;ZHANG Chuanlei;WANG Xinting;YUAN Changwei;CHEN Xiaoqi;CHEN Xinju(Department of Gastroenterology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan 450000,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301608,China;First School of Clinical Medicine,Henan University of Chinese Medicine,Zhengzhou,Henan 450046,China)

机构地区：[1]河南中医药大学第一附属医院消化科,河南郑州450000 [2]天津中医药大学,天津301608 [3]河南中医药大学第一临床医学院,河南郑州450046

出　　处：《中国医学工程》2025年第2期17-25,共9页China Medical Engineering

基　　金：国家科技重大专项-艾滋病和病毒性肝炎等重大传染病防治项目(2018ZX10303502);河南省特色骨干学科中医学第二批学科建设项目(STG-ZYX01-202101);河南省中医药科学研究专项课题(2022JDZX018)。

摘　　要：目的 白细胞介素7受体(IL-7R)为白细胞介素7 (IL-7)的受体,IL-7R在白血病中与免疫系统具有一定的相关性,但其在泛癌中的预后和免疫学价值尚未得到深入研究。该研究试图分析IL-7R在泛癌中的预后价值,并探讨IL-7R表达与免疫浸润之间的关系。方法 从癌症基因组图谱(TCGA)数据库中提取IL-7R的表达模式和泛癌肿瘤样本的临床信息。分析IL-7R表达与生存结局、肿瘤分期的相关性,绘制Kaplan-Meier曲线。预测IL-7R表达与免疫细胞含量和免疫细胞标志物类型的关系,寻找IL-7R在泛癌中的免疫学价值。结果 IL-7R的高表达有利于几种癌症的总体生存期(OS)、疾病特异性生存期(DSS)、无病生存期(DFS)和无进展生存期(PFS),而IL-7R表达使多形性胶质母细胞瘤(GBM)和脑低级别胶质瘤(LGG)的生存率恶化。IL-7R表达与21种癌症的肿瘤分期和预后相关,尤其是肝细胞肝癌(LIHC)、皮肤黑色素瘤(SKCM)和肺腺癌(LUAD)。此外,IL-7R表达与LIHC、LUAD和SKCM中的CD68+呈正相关。结论 IL-7R与多种肿瘤类型患者的预后及肿瘤免疫细胞浸润有关。IL-7R可能被认为是多种癌症预后的预测性生物标志物,因为它在免疫浸润中具有重要作用。【Objective】 IL-7R is the receptor of IL-7 and has a certain correlation with the immune system,but the specific mechanism and prognosis have not been thoroughly studied:whether it can be used as a new target of immunosuppressive therapy.The purpose of this study is to observe the prognosis of IL-7R in pan-cancer,and to explore the relationship between IL-7R expression and immune infiltration.【Methods】 The expression pattern of IL-7R and clinical information of pan cancer tumor samples were extracted from The Cancer Genome Atlas(TCGA) database.The correlation between IL-7R expression and survival outcomes,tumor staging were analyzed,and Kaplan-Meier curves were plotted.The relationship between IL-7R expression,immune cell content,and immune cell marker types were predictd,and the immunological value of IL-7R in pan-cancer was explored.【Results】 The high expression of IL-7R was beneficial for the overall survival(OS),disease-specific survival(DSS),disease-free survival(DFS),and progression free survival(PFS) of several cancers,while IL-7R expression deteriorated the survival rate of glioblastoma multiforme(GBM) and low-grade gliomas(LGG).IL-7R expression was associated with tumor staging and prognosis in 21 types of cancer,particularly liver hepatocellular carcinoma(LIHC),skin cutaneous melanoma(SKCM) and lung adenocarcinoma(LUAD).In addition,IL-7R expression was positively correlated with CD68+ in LIHC,LUAD,and SKCM.【Conclusion】 IL-7R is associated with prognosis and tumor immune cell infiltration in patients with multiple tumor types.It is suggested that IL-7R is a key factor in regulating the recruitment of immune cells to LIHC,LUAD and SKCM,playing an important role in regulating immune cell infiltration,and is a potential prognostic biomarker for patients with LIHC,LUAD and SKCM.

关 键 词：生物信息学分析 白细胞介素7受体 泛癌 预后 免疫 

分 类 号：R73-31[医药卫生—肿瘤]