化痰通络汤联合丁苯酞治疗对风痰阻络型急性脑梗死患者神经功能及血液流变学的影响  

Effects of Huatan Tongluo Decoction Combined with Butylphthalein on Nerve Function and Hemorheology in Patients with Wind-Phlegm-Blocked Collaterals Type Acute Cerebral Infarction

作　　者：李媛媛[1] LI Yuanyuan(Department of Encephalopathy,Pizhou Hospital of Traditional Chinese Medicine,Pizhou 221300,China)

机构地区：[1]邳州市中医院脑病科,江苏邳州221300

出　　处：《反射疗法与康复医学》2024年第24期13-16,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的分析化痰通络汤联合丁苯酞治疗风痰阻络型急性脑梗死(ACI)患者的应用效果。方法回顾性选取2022年1月—2023年12月邳州市中医院收治的92例风痰阻络型ACI患者的病例信息,按治疗方案将患者划分为两组,每组46例。两组患者均接受常规治疗,对照组采用丁苯酞治疗,观察组在对照组的基础上加用化痰通络汤治疗,两组均持续治疗20 d。对比两组患者的临床疗效、中医证候评分、神经功能、血液流变学及不良反应发生情况。结果观察组治疗总有效率为93.48%,高于对照组的78.26%,差异有统计学意义(P<0.05)。治疗后,观察组半身不遂、舌强言蹇、言语不利、头晕目眩、痰多且黏评分分别为(1.58±0.14)分、(1.37±0.09)分、(1.46±0.17)分、(0.74±0.09)分、(0.89±0.09)分,美国国立卫生研究院卒中量表评分为(7.76±1.01)分,全血低切粘度、全血高切粘度、红细胞压积分别为(8.94±1.30)mPa·s、(4.26±0.48)mPa·s、(37.53±3.36)%,均低于对照组的(2.26±0.27)分、(2.19±0.13)分、(2.37±0.25)分、(1.23±0.15)分、(1.34±0.10)分、(10.21±1.59)分、(12.25±1.68)mPa·s、(5.45±0.79)mPa·s、(42.46±4.09)%,组间差异有统计学意义(P<0.05)。两组均无不良反应。结论化痰通络汤联合丁苯酞可减轻护风痰阻络型ACI患者神经损伤,调节血液流变学,且无严重不良反应,具有一定的应用价值。Objective To analyze the effect of Huatan Tongluo Decoction combined with butylphthalein in the treatment of wind-phlegm-blocked collaterals type acute cerebral infarction(ACI).Methods Clinical data of 92 patients with wind-phlegm-blocked collaterals type ACI admitted to Pizhou Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were retrospectively selected.According to different treatment methods,patients were divided into two groups according to treatment regimen,with 46 cases in each group,both groups received conventional treatment,the control group was treated with butylphthalein,and the observation group was treated with Huatan Tongluo Decoction on the basis of the control group,Both groups were treated for 20 days.The clinical efficacy,Traditional Chinese Medicine syndrome score,nerve function,hemorheology and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.48%,which was higher than 78.26%of the control group,and the difference was statistically significant(P<0.05).After treatment,hemiplegia,strong tongue,adverse speech,dizziness,phlegm and viscosity scores in the observation group were(1.58±0.14)points,(1.37±0.09)points,(1.46±0.17)points,(0.74±0.09)points and(0.89±0.09)points,National Institute of Health Stroke Scale score was(7.76±1.01)points,whole blood low shear viscosity,whole blood high shear viscosity and hematocrit were(8.94±1.30)mPa·s,(4.26±0.48)mPa·s,(37.53±3.36)%,respectively,which were lower than(2.26±0.27)points,(2.19±0.13)points,(2.37±0.25)points,(1.23±0.15)points,(1.34±0.10)points,(10.21±1.59)points,(12.25±1.68)mPa·s,(5.45±0.79)mPa·s,(42.46±4.09)%of the control group,the differences between the groups were statistically significant(P<0.05).There were no adverse reactions in both groups.Conclusion uatan Tongluo Decoction combined with butylphthalein for patients with wind-phlegm obstructing collaterals type of ACI can alleviate nerve injury and regulate hemorheo

关 键 词：急性脑梗死 风痰阻络型 化痰通络汤 丁苯酞 不良反应 

分 类 号：R743[医药卫生—神经病学与精神病学]