甲状腺癌患者行甲状腺癌根治术后并发甲状旁腺功能减退的危险因素分析  

Analysis of Risk Factors for Hypoparathyroidism after Radical Thyroidectomy in Patients with Thyroid Cancer

作　　者：王新 WANG Xin(Department of Mammary Gland and Thyroid,Yinan County People's Hospital,Linyi Shandong,276300,China)

机构地区：[1]山东省沂南县人民医院乳腺甲状腺科,山东临沂276300

出　　处：《反射疗法与康复医学》2024年第24期114-116,120,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的分析甲状腺癌患者行甲状腺癌根治术(ROTC)后并发甲状旁腺功能减退(HP)的危险因素。方法回顾性分析2023年1月—2024年5月于沂南县人民医院行ROTC的150例甲状腺癌患者的临床资料,收集其一般情况,依据患者是否并发HP分为发生组与未发生组,探究其并发HP的危险因素。结果150例患者中,术后并发HP 46例,发生率为30.67%(46/150)。单因素分析显示,两组肿瘤直径、手术方式、淋巴结清扫范围、甲状旁腺误切、术前维生素D水平比较,组间差异有统计学意义(P<0.05)。多因素分析显示,肿瘤直径>4 cm、手术方式为开放性手术、淋巴结清扫范围为双侧、甲状旁腺误切、术前维生素D水平≤26 ng/mL是ROTC患者术后并发HP的独立危险因素(P<0.05)。结论ROTC患者术后HP的发生率相对较高,主要与肿瘤直径、手术方式、淋巴结清扫范围等因素有关,临床应制订相应措施进行干预。Objective To analyze the risk factors of hypoparathyroidism(HP)complicated after radical operation of thyroid cancer(ROTC)in patients with thyroid cancer.Methods The clinical data of one hundred and fifty patients with thyroid cancer who underwent ROTC in Yinan County People's Hospital from January 2023 to May 2024 were retrospectively analyzed,and their general conditions were collected.According to whether the patients had HP or not,the patients were divided into the developing group and the non-developing group,the risk factors of HP were explored.Results Among the 150 patients,46 cases were complicated by HP after operation,the incidence was 30.67%(46/150).Univariate analysis showed that tumor diameter,surgical method,lymph node dissection range,parathyroidectomy and preoperative vitamin D level were compared between the two groups,the differences between the groups were statistically significant(P<0.05).Multivariate analysis showed that tumor diameter>4 cm,operation method was open operation,bilateral lymph node dissection,parathyroidectomy,and preoperative vitamin D level≤26 ng/mL were the independent risk factors for postoperative HP in ROTC patients(P<0.05).Conclusion The incidence of postoperative HP in ROTC patients is relatively high,which is mainly related to tumor diameter,operation method,lymph node dissection range and other factors.Clinical intervention measures should be developed.

关 键 词：甲状腺癌 甲状腺癌根治术 甲状旁腺功能减退 现状调查 危险因素 干预措施 

分 类 号：R736.1[医药卫生—肿瘤]