经尿道钬激光膀胱肿瘤切除术与经尿道膀胱肿瘤电切术治疗非肌层浸润性膀胱癌患者的效果对比  

Effect of Transurethral Holmium Laser Resection of Bladder Tumor Compared with Transurethral Resection of Bladder Tumor in the Treatment of Non-Muscular Invasive Bladder Cancer

作　　者：任云鹏 康郑军[2] REN Yunpeng;KANG Zhengjun(Department of Wound Repair,The First Affiliated Hospital of Nanyang Medical College,Nanyang 473003,China;Department of Urology,The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院创面修复科,河南南阳473003 [2]郑州大学第五附属医院泌尿外科,河南郑州450000

出　　处：《反射疗法与康复医学》2024年第24期150-153,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨非肌层浸润性膀胱癌(NMIBC)应用经尿道钬激光膀胱肿瘤切除术(THLRBT)与经尿道膀胱肿瘤电切术(TURBT)的不同疗效。方法选取2021年1月—2023年4月南阳医学高等专科学校第一附属医院收治的82例NMIBC患者为研究对象,采用随机数字表法将其分为对照组和观察组,各41例。对照组采用TURBT治疗,观察组采用THLRBT治疗。对比两组的围术期相关指标、血清肿瘤标志物、并发症发生情况及术后1年复发情况。结果观察组手术、术后膀胱冲洗、尿管留置及住院时间均短于对照组,术中出血量少于对照组,组间差异有统计学意义(P<0.05);两组术后下床时间比较,差异无统计学意义(P>0.05)。术后,观察组血清糖类抗原19-9、胰岛素样生长因子-Ⅰ、基质金属蛋白酶-9水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组并发症发生率为4.88%,低于对照组的24.39%,术后1年复发率为7.32%,低于对照组的24.39%,组间差异有统计学意义(P<0.05)。结论相较于传统TURBT,NMIBC患者采用THLRBT治疗可取得更为显著的疗效,可有效改善围术期相关指标,降低血清肿瘤标志物水平及并发症发生率,且术后1年疾病复发率更低。Objective To investigate the differences efficacy of transurethral holmium laser resection of bladder tumor(THLRBT)and transurethral resection of bladder tumor(TURBT)in the treatment of non-muscle invasive bladder cancer(NMIBC).Methods A total of 82 NMIBC patients admitted to the First Affiliated Hospital of Nanyang Medical College from January 2021 to April 2023 were selected as the research objects,they were divided into a control group and an observation group by the random number table method,with 41 cases in each group.The control group was treated with TURBT,and the observation group was treated with THLRBT.The perioperative related indicators,serum tumor markers,occurrence of complications and recurrence 1 year after operation were compared between the two groups.Results The operation,postoperative bladder irrigation,catheter indwelling and hospitalization time of the observation group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group,the differences between the groups were statistically significant(P<0.05);there was no significant difference in the time of getting out of bed after operation between the two groups(P>0.05).After operation,the levels of serum carbohydrate antigen 19-9,insulin-like growth factor-I and matrix metalloproteinase-9 in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of complications in the observation group was 4.88%,which was lower than 24.39%in the control group,and the recurrence rate 1 year after operation was 7.32%,which was lower than 24.39%in the control group,the differences between the groups were statistically significant(P<0.05).Conclusion Compared with traditional TURBT,THLRBT can achieve more significant curative effect in patients with NMIBC,which can effectively improve perioperative related indicators,reduce serum tumor marker levels and the incidence of complications,and has a lower diseas

关 键 词：非肌层浸润性膀胱癌 经尿道膀胱肿瘤电切术 经尿道钬激光膀胱肿瘤切除术 血清肿瘤标志物 并发症 复发 

分 类 号：R737.14[医药卫生—肿瘤]