婴儿痉挛症治疗的研究进展  

Progress on the treatment of infantile spasm

作　　者：尤铭洋 马福艳 霍亮[1] You Mingyang;Ma Fuyan;Huo Liang(Department of Pediatric Neurology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院小儿神经内科,沈阳110004

出　　处：《国际儿科学杂志》2025年第1期38-42,共5页International Journal of Pediatrics

基　　金：中国抗癫痫协会癫痫科研基金(CX-B-2021-02);辽宁省科技厅中国医科大学高质量发展科技资金项目(2023JH/20200119)。

摘　　要：婴儿痉挛症是一种年龄特异性癫痫性脑病,且多为药物难治性,随着年龄增长容易转化为其他类型癫痫,多数患儿预后不佳,伴随神经发育障碍。促肾上腺皮质激素、糖皮质激素和氨己烯酸是目前治疗婴儿痉挛症的一线药物,但应用一线药物后患儿痉挛控制率、脑电图缓解率和复发率并不理想,急需寻找更有效的治疗方案。由于婴儿痉挛症的病因复杂多样,针对病因学治疗方案的研究有许多不同的观点。目前更有效地控制痉挛、改善预后、个体化治疗和靶向治疗是婴儿痉挛症的研究热点。该文主要综述婴儿痉挛症的治疗现状及一些尚未进入临床广泛应用的新兴疗法。Infantile spasm is an age-related epileptic encephalopathy,most are drug-resistant,as the chirldren grow older,it will transfer into other epileptic syndrome.Most chirldren have a bad prognosis with neurodevelomental disorders.For now,aderenocortitropic hormone,glucocorticoid and vigabatrin are first-line treatment choice.But the control rate of spasm、remission rate of EEG and recurrence rate after first-line treatment are not ideal.It's necessary to find more effective treatment plans desperately.Considering the diversity and complexity of infantile spasm's etiologies,there are a lot of studies about treatment plan based on etiology.Controlling spasm more effectively,improving prognosis,personalized therapy and targeted therapy become the new focus.This article reviews the current treatment status of infantile spasm,also upates some novel methods which is not widely applied in clinical practice.

关 键 词：婴儿痉挛症 癫痫综合征 难治性癫痫 传统治疗 新兴治疗 

分 类 号：R74[医药卫生—神经病学与精神病学]