血清CA19-9、HMGB1、UMOD对急性胆囊炎严重程度的诊断价值  

Diagnostic Value of Serum CA19-9,HMGB1 and UMOD for the Severity of Acute Cholecystitis

作　　者：郑博文 ZHENG Bowen(Emergency Department of Zhoukou Traditional Chinese Medicine Hospital,Henan Zhoukou 466000,China)

机构地区：[1]周口市中医院急诊科,河南周口466000

出　　处：《中国医药导刊》2024年第12期1237-1240,共4页Chinese Journal of Medicinal Guide

摘　　要：目的:探究血清糖类抗原19-9(CA19-9)、高迁移率族蛋白1(HMGB1)、尿调节素(UMOD)水平与急性胆囊炎(AC)患者病情程度的相关性及临床应用价值。方法:选取2022年1月至2023年8月我院诊疗的99例AC患者纳入研究组,另选取同期99例健康体检者纳入对照组。比较两组及不同病情程度AC患者入院时血清CA19-9、HMGB1、UMOD水平,分析其与病情程度的相关性及联合检测效能。结果:研究组血清CA19-9、HMGB1水平高于对照组,UMOD水平低于对照组(P<0.05)。不同病情程度AC患者血清CA19-9、HMGB1水平比较:轻度患者<中度患者<重度患者;UMOD水平比较:重度患者<中度患者<轻度患者(P<0.05)。AC患者入院时血清CA19-9、HMGB1水平与病情程度呈正相关,UMOD水平与病情程度呈负相关(P<0.05)。以中度AC患者为阳性样本,以轻度AC患者为阴性样本,血清CA19-9、HMGB1、UMOD水平联合检测的AUC为0.824(P<0.05);以重度AC患者为阳性样本,以中度AC患者为阴性样本,血清CA19-9、HMGB1、UMOD水平联合检测的AUC为0.837(P<0.05)。结论:血清CA19-9、HMGB1、UMOD水平与AC患者病情程度密切相关,可作为临床判断病情程度、制定诊疗方案的参考指标。Objective:To investigate the correlation between serum carbohydrate antigen 19-9(CA19-9),high mobility group box 1 protein(HMGB1),uromodulin(UMOD)levels and the severity of acute cholecystitis(AC).Methods:A total of 99 patients with AC treated in our hospital from January 2022 to August 2023 were included in the study group,and 99 healthy subjects were included in the control group during the same period.The serum CA19-9,HMGB1 and UMOD levels were compared between the two groups and patients with different degrees of AC at the time of admission,and their correlation with the degree of disease and the efficacy of the combined test were analyzed.Results:The serum levels of CA19-9 and HMGB1 of patients in the study group were higher than those in the control group,and the serum level of UMOD was lower than that in the control group(P<0.05).The levels of serum CA19-9 and HMGB1 of patients with different disease degrees were compared:mild patients<moderate patients<severe patients.Serum UMOD levels were compared:severe patients<moderate patients<mild patients(P<0.05).The levels of serum CA19-9 and HMGB1 were positively correlated with the severity of AC,while the levels of UMOD were negatively correlated with the severity of AC(P<0.05).With moderate AC patients as positive samples and mild AC patients as negative samples,the AUC of serum CA19-9,HMGB1 and UMOD combined detection was 0.824(P<0.05).With patients with severe AC as positive samples and patients with moderate AC as negative samples,the AUC of the combined detection of serum CA19-9,HMGB1 and UMOD levels was 0.837(P<0.05).Conclusion:Serum CA19-9,HMGB1,UMOD levels are closely related to the degree of disease in AC patients,and can be used as a reference index to judge the severity of AC and make diagnosis and treatment plan.

关 键 词：血清 糖类抗原19-9 高迁移率族蛋白1 尿调节素 急性胆囊炎 

分 类 号：R575.6[医药卫生—消化系统]