40~65岁人群睡眠效率与血脂异常关联性研究  

Association between Sleep Efficiency and Dyslipidemia among Adults Aged 40 to 65

作　　者：汪蝶 吴帮云 谭存瑶 谌世晖 李游 蒙玥 王大珊 胡瑾[1] 王子云[1] 汪俊华[1] WANG Die;WU Bangyun;TAN Cunyao;SHEN Shihui;LI You;MENG Yue;WANG Dashan;HU Jin;WANG Ziyun;WANG Junhua(School of Public Health,Guizhou Medical University/the key Laboratory of Environmental Pollution Monitoring and Disease Control,Guian New Area 561113,China;Fuquan Center For disease Control and prevention,Fuquan 550599,China)

机构地区：[1]贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室,贵州省贵安新区561113 [2]贵州省黔南布依族苗族自治州福泉市疾病预防控制中心,550599

出　　处：《中国全科医学》2025年第13期1601-1606,共6页Chinese General Practice

基　　金：国家自然科学基金资助项目(81960612);贵州省科技计划项目(黔科合基础-ZK[2022]一般382)。

摘　　要：背景中老年人的睡眠效率(SE)降低可能影响其血脂代谢,需进一步深入分析。目的分析40~65岁人群SE与不同血脂指标间的关联,探讨中心性肥胖在SE与血脂关联间的中介作用,为探讨SE导致血脂异常的途径及血脂异常的防治提供参考依据。方法于2022年3—11月对在福泉市第一人民医院体检中心体检的符合纳入与排除标准的对象进行调查,包括面对面问卷调查、体格检查、实验室指标检测三部分。通过有向无环图(DAG)识别SE与血脂异常的关联上所需要调整的最小控制变量集为:年龄、性别、吸烟、饮酒、家庭收入、运动及文化程度。采用非条件二分类Logistic回归分析探讨SE与不同血脂异常指标间的关联。结果本研究最终纳入1095名调查对象,根据血脂异常与否分组。两组性别、吸烟、饮酒、运动、腰围、臀围及腰臀比比较,差异有统计学意义(P<0.05),调整控制变量后与高SE人群相比,低SE人群发生高三酰甘油(TG)血症的风险增加(OR=1.35,95%CI=1.03~1.77),SE与其他血脂指标无关联。中介效应分析显示腰臀比(WHR)在SE与高TG血症的关联中具有部分中介作用(β=0.019,95%CI=0.005~0.034),中介效应占比为32.76%。WHR在SE与低高密度脂蛋白胆固醇(HDL-C)血症的关联中具有遮掩效应。结论WHR可能是低SE与高TG血症关联中的重要路径。Background Lipid metabolism of middle-aged and older adults may be influenced by decreased sleep efficiency,but their association still needs to be analyzed in-depth.Objective To analyze the association between sleepefficiency(SE)and different lipid indexes in people aged 40-65,and to explore the mediating role of central obesity in the association between SE and lipid to provide reference for exploring the pathway of dyslipidemia caused by SE and its prevention and treatment.Methods From March to November 2022,the subjects who met the inclusion and exclusion criteria for physical examination in the physical examination center of Fuquan First People's Hospital were investigated,including face-to-face questionnaire survey,physical examination and laboratory index detection.The minimum control variable set that needs to be adjusted to identify the association between SE and dyslipidemia through directed acyclic graph(DAG)was:age,gender,smoking,drinking,family income,exercise and education level.Non-conditional binary Logistic regression analysis was used to explore the association between SE and different dyslipidemia indicators.Results A total of 1095 subjects were included in this study and were divided into two groups according to the presence or absence of dyslipidemia.There were statistically significant differences in gender,smoking,drinking,exercise,waist circumference,hip circumference and waist-hip ratio between the two groups(P<0.05).After adjusting control variables,higher risk hypertriglyceridemia was observed in the group with low SE than high SE group(OR=1.35,95%CI=1.03-1.77),there was no statically significant association between SE and other lipid indexes.Mediation effect analysis showed that WHR had a partial mediating effect in the association between SE and hypertriglyceridemia(β=0.019,95%CI=0.005-0.034),WHR played a masking effect on the association between SE and low high-density lipoprotein cholesterol.Conclusion Central obesity may be an important pathway in the association between low SE an

关 键 词：睡眠效率 血脂异常 关联性 中老年人 

分 类 号：R338.63[医药卫生—人体生理学]