丁苯酞联合阿替普酶治疗对急性脑梗死患者脑血流速度及神经功能的影响  

Effects of Butylphthalein Combined with Alteplase on Cerebral Blood Flow Velocity and Nerve Function in Patients with Acute Cerebral Infarction

作　　者：张敬 ZHANG Jing(Department of Neurology,Caoxian People's Hospital,Heze 274400,China)

机构地区：[1]曹县人民医院神经内科,山东菏泽274400

出　　处：《反射疗法与康复医学》2024年第23期145-148,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨丁苯酞联合阿替普酶治疗对急性脑梗死(ACI)患者脑血流速度及神经功能的影响。方法回顾性分析2022年1月—2023年10月于曹县人民医院收治的130例ACI患者的临床资料,根据治疗方式的不同将其分为对照组和观察组,各65例。对照组采用阿替普酶治疗,观察组在对照组基础上采用丁苯酞治疗。对比两组的临床疗效、脑血流速度、神经功能及不良反应发生情况。结果观察组治疗总有效率为87.69%,高于对照组的73.85%,差异有统计学意义(P<0.05)。治疗后,观察组大脑后动脉、大脑中动脉、大脑前动脉的血流速度均快于对照组,组间差异有统计学意义(P<0.05);观察组美国国立卫生研究院卒中量表评分低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论丁苯酞联合阿替普酶治疗ACI患者的疗效显著,可改善患者的脑血流速度和神经功能,且安全性良好。Objective To investigate the effects of butylphthalein combined with alteplase on cerebral blood flow velocity and nerve function in patients with acute cerebral infarction(ACI).Methods The clinical data of 130 ACI patients admitted to Caoxian People's Hospital from January 2022 to October 2023 were retrospectively analyzed,according to different treatment methods,they were divided into a control group and an observation group,with 65 cases in each group.The control group was treated with alteplase,and the observation group was treated with butylphthalein on the basis of the control group.The clinical efficacy,cerebral blood flow velocity,nerve function and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 87.69%,which was higher than 73.85%of the control group,the difference was statistically significant(P<0.05).After treatment,the blood flow velocity of posterior cerebral artery,middle cerebral artery and anterior cerebral artery in observation group were faster than those in control group,and the differences between the groups were statistically significant(P<0.05);the National Institutes of Health Stroke Scale score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Butylphthalein combined with alteplase is effective in the treatment of ACI patients,which can improve cerebral blood flow velocity and nerve function with good safety.

关 键 词：急性脑梗死 丁苯酞 阿替普酶 脑血流速度 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]