宫颈癌放疗联合化疗所致放射性肠炎危险因素分析  

Analysis of risk factors of radiation enteritis induced by radiotherapy and chemotherapy for cervical cancer

作　　者：刘颖 陆试鹏 刘子豪 高璨 祁兴顺 彭娅 LIU Ying;LU Shi-peng;LIU Zi-hao;GAO Can;QI Xing-shun;PENG Ya(Hunan Occupational Disease Prevention and Control Institute,Changsha 410007,China;Department of Gastroenterology,First Affiliated Hospital of Hunan Normal University(Hunan People′s Hospital),Changsha 410005,China;Endoscopy Center,Hunan Cancer Hospital,Changsha 410006,China;Department of Gastroenterology,General Hospital of Northern Theater Command,Shenyang 110016,China)

机构地区：[1]湖南省职业病防治院,湖南长沙410007 [2]湖南师范大学第一附属医院(湖南省人民医院)消化内科,湖南长沙410005 [3]湖南省肿瘤医院内镜中心,湖南长沙410006 [4]北部战区总医院消化内科,辽宁沈阳110016

出　　处：《临床军医杂志》2025年第2期147-150,共4页Clinical Journal of Medical Officers

基　　金：湖南省自然科学基金面上项目(2023JJ30348)。

摘　　要：目的探讨宫颈癌放疗联合化疗所致放射性肠炎(RE)的危险因素。方法选取湖南师范大学第一附属医院与湖南省肿瘤医院自2017年1月至2023年3月收治的109例行放疗联合化疗的宫颈癌患者为研究对象。根据是否发生RE,将患者分为A组(未发生RE,n=44)与B组(发生RE,n=65)。收集并比较两组患者的一般资料。采用单因素及多因素Logistic回归分析筛选宫颈癌放疗联合化疗所致RE的危险因素。结果两组患者年龄、国际妇产科协会分期、营养状况比较,差异均有统计学意义(P<0.05);B组患者合并糖尿病、放疗时间>8周、平均照射剂量>50 cGy、粪便隐血试验阳性比例均高于A组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,年龄>60岁、合并糖尿病、营养状况欠佳、放疗时间>8周、平均照射剂量>50 cGy、粪便隐血试验结果阳性均为宫颈癌放疗联合化疗所致RE的独立危险因素(P<0.05)。结论宫颈癌患者放疗联合化疗后发生RE与年龄、自身营养状况、合并糖尿病、放疗时间、照射剂量及粪便隐血试验结果密切相关。Objective To investigate the risk factors of radiation enteritis(RE)caused by radiotherapy combined with chemotherapy for cervical cancer.Methods A total of 109 patients with cervical cancer receiving radiotherapy combined with chemotherapy from the First Affiliated Hospital of Hunan Normal University and Hunan Cancer Hospital from January 2017 to March 2023 were selected as the study objects.Patients were divided into group A(no RE,n=44)and group B(RE,n=65)according to whether RE occurred.General data of the two groups were collected and compared.Single factor and multiple factor Logistic regression analysis were used to screen the risk factors of cervical cancer RE caused by radiotherapy combined with chemotherapy.Results There were significant differences in age,stage of federation international of gynecology and obstetrics and nutritional status between the two groups(P<0.05).Patients in group B with diabetes mellitus,radiotherapy time>8 weeks,average irradiation dose>50 cGy,fecal occult blood test positive ratio were higher than group A,the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that age>60 years old,diabetes mellitus,poor nutritional status,duration of radiotherapy>8 weeks,average irradiation dose>50 cGy and positive results of fecal occult blood test were all independent risk factors for RE caused by cervical cancer radiotherapy combined with chemotherapy(P<0.05).Conclusion The incidence of RE in patients with cervical cancer after radiotherapy combined with chemotherapy is closely related to age,nutritional status,diabetes mellitus,radiotherapy time,irradiation dose and results of fecal occult blood test.

关 键 词：宫颈癌 放射性肠炎 放疗联合化疗 危险因素 

分 类 号：R737.33[医药卫生—肿瘤]