脑卒中相关性肌少症的患病率及危险因素的Meta分析  

Incidence and Risk Factors of Stroke-Related Sarcopenia:a Meta-analysis

作　　者：王健翔 殷小焦 穆茂容 高云[1] WANG Jianxiang;YIN Xiaojiao;MU Maorong;GAO Yun(Department of Neurosurgery,the First Hospital of Kunming,Kunming 650000,China;School of Nursing,Kunming Medical University,Kunming 650500,China)

机构地区：[1]云南省昆明市第一人民医院神经外科,650000 [2]昆明医科大学护理学院,云南省昆明市650500

出　　处：《实用心脑肺血管病杂志》2025年第4期57-63,共7页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：昆明市卫生科研课题项目(2021-14-02-0010)。

摘　　要：目的 系统评价脑卒中相关性肌少症的患病率及危险因素。方法 计算机检索PubMed、Embase、Web of Science、Cochrane Library、Scopus、中国知网、万方数据知识服务平台、维普网公开发表的脑卒中相关性肌少症的患病率及危险因素的文献,检索时间为建库至2024年9月。由2名培训合格的研究人员独立进行文献筛选、资料提取及质量评价,使用Stata 15.0软件进行Meta分析。结果 本研究纳入18篇文献,共5 315例脑卒中患者,脑卒中相关性肌少症患病率为8%~68%。共筛选出16种脑卒中相关性肌少症的危险因素。Meta分析结果显示,脑卒中相关性肌少症的患病率为31.1%[95%CI(23.6%~39.1%)]。年龄≥60岁[OR=1.08,95%CI(1.05~1.12)]、BMI≤18.5kg/m^(2)[OR=1.10,95%CI(1.05~1.18)]、卒中史[OR=1.28,95%CI(1.05~1.55)]、合并糖尿病[OR=1.60,95%CI(1.15~2.22)]、肺部感染[OR=1.76,95%CI(1.04~2.18)]、白蛋白<35 g/L[OR=4.27,95%CI(2.62~6.97)]、鼻饲喂养[OR=2.48,95%CI(1.38~4.45)]、骨质疏松[OR=2.42,95%CI(1.95~2.99)]、肌力下降[OR=2.04,95%CI(1.43~2.90)]、美国国立卫生研究院卒中量表(NIHSS)评分>15分[OR=1.14,95%CI(1.10~1.39)]、住院时间延长[OR=1.27,95%CI(1.11~1.46)]是脑卒中相关性肌少症的危险因素(P<0.05)。结论 现有证据显示,脑卒中相关性肌少症患病率较高,为31.1%;年龄≥60岁、BMI≤18.5 kg/m^(2)、卒中史、合并糖尿病、肺部感染、白蛋白<35 g/L、鼻饲喂养、骨质疏松、肌力下降、NIHSS评分>15分、住院时间延长是脑卒中相关性肌少症的危险因素。Objective To systematically evaluate the incidence and risk factors of stroke-related sarcopenia.Methods Databases including the PubMed,Embase,Web of Science,Cochrane Library,Scopus,CNKI,Wanfang Data,VIP were retrieved to search for studies on the incidence and risk factors of stroke-related sarcopenia.The search period was from inception to September 2024.Literature screening,data extraction and quality assessment were performed independently by two trained and qualified researchers.Stata 15.0 was used for meta-analysis.Results A total of 18 articles were included,and involving 5315 stroke patients,incidence of stroke-related sarcopenia ranged from 8%to 68%.Meta-analysis results showed that incidence of stroke-related sarcopenia was 31.1%[95%CI(23.6%-39.1%)].Age≥60 years old[OR=1.08,95%CI(1.05-1.12)],BMI≤18.5 kg/m^(2)[OR=1.10,95%CI(1.05-1.18)],history of stroke[OR=1.28,95%CI(1.05-1.55)],combined diabetes[OR=1.60,95%CI(1.15-2.22)],pulmonary infection[OR=1.76,95%CI(1.04-2.18)],albumin<35 g/L[OR=4.27,95%CI(2.62-6.97)],nasal feeding[OR=2.48,95%CI(1.38-4.45)],osteoporosis[OR=2.42,95%CI(1.95-2.99)],decreased muscle strength[OR=2.04,95%CI(1.43-2.90)],National Institute of Health Stroke Scale(NIHSS)score>15 points[OR=1.14,95%CI(1.10-1.39)],extended hospitalization time[OR=1.27,95%CI(1.11-1.46)]were the risk factors of stroke-related sarcopenia(P<0.05).Conclusion The available evidence shows that the incidence of stroke-related sarcopenia is relatively high(31.1%),age≥60 years old,BMI≤18.5 kg/m^(2),history of stroke,combined diabetes,pulmonary infection,albumin<35 g/L,nasal feeding,osteoporosis,decreased muscle strength,NIHSS score>15 points,extended hospitalization time are the risk factors of strokerelated sarcopenia.

关 键 词：卒中 肌减少症 患病率 危险因素 META分析 

分 类 号：R743[医药卫生—神经病学与精神病学] R746.4[医药卫生—临床医学]