羟基红花黄色素A治疗缺血性脑卒中的机制  

Mechanism of Hydroxysafflor Yellow A in the Treatment of Ischemic Stroke

作　　者：舒梦琦 戴瑶瑶 宋丽娟 马东[3] 马存根[1] 黄建军 SHU Mengqi;DAI Yaoyao;SONG Lijuan;MA Dong;MA Cungen;HUANG Jianjun(State Administration of Traditional Chinese Medicine Key Laboratory of Multiple Sclerosis,Qi and Activating Blood/Neurobiology Research Center,Shanxi University of Chinese Medicine,Jinzhong 030619,China;Ministry of Education Key Laboratory of Cell Physiology,Shanxi Medical University,Taiyuan 030032,China;Neurosurgery,General Hospital of Sinopharm Tongmei Group,Datong 037003,China)

机构地区：[1]山西中医药大学国家中医药管理局多发性硬化益气活血重点研究室神经生物学研究中心,山西省晋中市030619 [2]山西医科大学细胞生理学省部共建教育部重点实验室,山西省太原市030032 [3]国药同煤集团总医院神经外科,山西省大同市037003

出　　处：《实用心脑肺血管病杂志》2025年第4期113-116,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目(82004028);山西省研究生科研创新项目(2023KY677);山西中医药大学学科建设经费(2023XKJS-02)。

摘　　要：缺血性脑卒中(IS)主要以脑血管的急速堵塞为特点,可造成脑组织不可逆性损伤,目前其发病逐渐年轻化,且致残、致死率较高,这加重了社会经济负担。本文以中药材红花中的主要成分羟基红花黄色素A(HSYA)作为切入点,简述了其口服和静脉滴注的药代动力学特点,同时论述了HSYA治疗IS的机制,包括抑制氧化应激、抑制炎症反应、促进血管新生、调控细胞自噬,这可为后续HSYA在临床上的实际应用提供一定参考。Ischemic stroke(IS)is mainly characterized by rapid blockage of cerebral vessels,which can cause irreversible damage to brain tissue.At present,the incidence of IS is gradually younger,and the disability and fatality rate are high,which increases the social and economic burden.In this paper,hydroxysafflor yellow A(HSYA),the main component of safflower in traditional Chinese medicine,was taken as an entry point to briefly describe its pharmacokinetic characteristics in oral and intravenous infusion,at the same time,this paper discussed the mechanism of HSYA in the treatment of IS,including inhibition of oxidative stress,inhibition of inflammation,promotion of angiogenesis,regulation of autophagy,which can provide some reference for the subsequent practical application of HSYA in clinical practice.

关 键 词：缺血性卒中 羟基红花黄色素A 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]