结直肠癌患者一级亲属结肠镜筛查行为影响因素的Meta分析  

Meta-analysis of influencing factors of colonoscopy screening behavior of first-degree relatives of patients with colorectal cancer

作　　者：马改荣 宋燕[1] 阮春凤[1] 赵新鲜[1] MA Gairong;SONG Yan;RUAN Chunfeng;ZHAO Xinxian(Department of Nursing,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院护理部,上海200127

出　　处：《肿瘤》2024年第7期778-785,共8页Tumor

基　　金：上海市护理学会科研课题重点项目(2022SD-B01)

摘　　要：目的:对结直肠癌患者一级亲属结肠镜筛查行为影响因素进行Meta分析,为提高结肠镜筛查率提供依据。方法:检索PubMed、Cochrane Library、Web of Science、CINAHL、Embase、中国生物医学文献数据库、中国知网、万方数据和维普数据库中从建库至2024年7月1日发表的有关结直肠癌患者一级亲属结肠镜筛查行为影响因素的所有文献及其参考文献,由2名研究者按照标准独立筛选文献、提取资料和评价文献质量。采用Stata 18.0软件对结肠镜筛查行为的影响因素进行Meta分析。结果:共纳入文献11篇,样本总量为30985例。Meta分析结果显示,结直肠癌患者一级亲属的结肠镜筛查率为35.30%(95%CI:24.30%~46.20%),一级亲属文化程度[OR:1.586(95%CI:1.239~2.032)]、结直肠癌预防和筛查知识[OR:2.319(95%CI:1.626~3.307)]、感知易感性[OR:1.301(95%CI:1.145~1.478)]、感知障碍[OR:2.162(95%CI:1.081~4.328)]、和行动线索[OR:4.170(95%CI:2.686~6.469)]是影响结直肠癌患者一级亲属结肠镜筛查行为的重要因素。结论:结直肠癌患者一级亲属结肠镜筛查率有待进一步提高,其结肠镜筛查行为受多种因素影响。今后可参考本研究结果,识别高危人群,采取多元化、针对性的干预措施,提高结直肠癌患者一级亲属结肠镜筛查率,进一步提高中国结直肠癌的早期检出率。Objective:Meta-analysis of influencing factors of colonoscopy screening behavior of firstdegree relatives of patients with colorectal cancer was conducted to provide basis for improving the rate of colonoscopy screening.Methods:The literatures and their references related to the influencing factors of colonoscopy screening behavior of first-degree relatives of colorectal cancer patients from the establishment of the database to July 1,2024 were searching in PubMed,Cochrane Library,Web of Science,CINAHL,Embase,China Biomedical Literature Database,China National Knowledge Infrastructure,Wanfang Database and VIP Database.The literatures were extracted and evaluated by two researchers independently according to the standards.In this study,the influencing factors of colonoscopy screening behavior were analyzed by Stata 18.0 software.Results:A total of 11 literatures were included,with a total sample size of 30985 cases.The results of Meta-analysis showed that the colonoscopy screening rate of first-degree relatives of colorectal cancer patients was 35.30%(95%CI:24.30%-46.20%).First-degree relatives'education level[OR:1.586(95%CI:1.239-2.032)],colorectal cancer prevention and screening knowledge[OR:2.319(95%CI:1.626-3.307)],and perceived susceptibility[OR:1.301(95%CI:1.081-4.328)]and cues to action[OR:4.170(95%CI:2.686-6.469)]were the important factors influencing the colonoscopy screening behavior of the firstdegree relatives of patients with colorectal cancer.Conclusion:The colonoscopy screening rate of first-degree relatives of colorectal cancer patients needs to be further improved,and the colonoscopy screening behavior is influenced by many factors.In the future,the results of this study can be referenced,in order to identify high-risk groups,take diversified and targeted intervention measures,improve the colonoscopy screening rate of first-degree relatives of colorectal cancer patients,and further improve the early detection rate of colorectal cancer in China.

关 键 词：结直肠癌 一级亲属 结肠镜筛查 影响因素分析 META分析 

分 类 号：R735.34[医药卫生—肿瘤]