血清神经丝轻链蛋白、过氧化还原蛋白1水平与Wilson病患者神经及认知功能的相关性分析  

Correlation analysis between serum neurofilament light and peroxiredoxin 1 levels and the neurological and cognitive function of patients with Wilson's disease

作　　者：李良勇[1] 唐露露 李亚军[1] 梅灯 汪瀚[1] LI Liangyong;TANG Lulu;LI Yajun(Department of Neurology,Anhui University of Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽中医药大学第一附属医院神经内科,合肥230031

出　　处：《临床神经病学杂志》2024年第6期418-421,共4页Journal of Clinical Neurology

基　　金：国家自然科学基金青年项目(82205076);安徽省高等学校自然科学基金项目(2023AH050828)。

摘　　要：目的 探讨Wilson病(WD)患者血清神经丝轻链蛋白(NfL)、过氧化还原蛋白1(PRDX1)水平与神经和认知功能的相关性。方法 选取2022年4月至2024年4月我院收治的120例WD患者为研究对象,根据神经功能(改良Young量表)及认知功能(MMSE量表)水平将患者分级。同时选取30名同期我院的健康体检者为正常对照组。通过ELISA法测定研究对象NfL和PRDX1水平,采用Pearson相关分析探讨神经功能和认知功能与血清NfL、PRDX1水平的相关性。结果 WD患者血清NfL、PRDX1水平较正常对照组显著升高(均P<0.05),神经功能评分高的WD患者的血清NfL、PRDX1水平明显高于神经功能评分低的WD患者(均P<0.05),WD患者神经功能评分与血清NfL、PRDX1水平呈正相关(均P<0.05);认知功能损害的WD患者的血清NfL、PRDX1水平较正常对照组显著升高(均P<0.05),而认知功能评分低的WD患者的血清NfL、PRDX1水平明显高于认知功能评分高的WD患者(均P<0.05),WD患者认知功能评分与血清NfL、PRDX1水平呈负相关(均P<0.05)。结论 血清NfL、PRDX1水平与WD患者神经及认知功能损害及损害的严重程度密切相关,二者可能可作为评估WD患者神经功能或认知功能损害的辅助生物学指标。Objective To evaluate correlations between levels of neurofilament light(NfL)and peroxiredoxin 1(PRDX1)in the serum of Wilson's disease(WD)patients and their neurological and cognitive function.Methods In total,this study included 120 WD patients who were admitted to our hospital between April 2022 and April 2024.WD patient classification was performed based on analyses of neurological function(Modified Young Scale)and cognitive function(MMSE scales).As normal control subjects,30 healthy volunteers who completed health examinations at our hospital over this same time period were enrolled as normal control group.Serum NfL and PRDX1 levels were detected via ELISA,and Pearson correlation analyses were used to assess correlations between the serum levels of these proteins and WD patient neurological and cognitive function.Results Significantly increased serum NfL and PRDX1 levels were observed in WD patients relative to normal control group(all P<0.05),and the levels of serum NfL and PRDX1 in the serum of WD patients exhibiting high neurological function scores were significantly higher than those in WD patients exhibiting low neurological function scores(all P<0.05).Positive correlations were observed between these WD patient neurological function scores and serum levels of both NfL and PRDX1(all P<0.05).Moreover,WD patients with cognitive impairment exhibited significantly elevated serum NfL and PRDX1 levels as compared to normal control group(all P<0.05),and the serum levels of NfL and PRDX1 in WD patients with lower cognitive function scores were significantly higher than those with higher cognitive function scores(all P<0.05).A negative correlation was detected between WD patient cognitive function scores and serum levels of both NfL and PRDX1(all P<0.05).Conclusion NfL and PRDX1 serum levels are closely related to the severity of neurological and cognitive impairment in WD patients,and they may offer utility as auxiliary biomarkers for the assessment of cognitive and neurological impairment in patients with WD.

关 键 词：WILSON病 神经丝轻链蛋白 过氧化还原蛋白1 认知功能 

分 类 号：R742.4[医药卫生—神经病学与精神病学]