加味桂枝茯苓丸联合达那唑对子宫肌瘤患者肌瘤体积及性激素水平的影响  

Effects of modified Guizhi Fuling Pills combined with danazol on the myoma volume and sex hormone levels in patients with uterine myoma

作　　者：涂丽华 TU Lihua(Yongfeng County Traditional Chinese Medical Hospital,Yongfeng County 331500,Jiangxi Province,China)

机构地区：[1]江西省吉安市永丰县中医院,永丰县331500

出　　处：《内科》2024年第6期637-641,共5页Internal Medicine

摘　　要：目的探讨加味桂枝茯苓丸联合达那唑对子宫肌瘤(UM)患者肌瘤体积及性激素水平的影响。方法选取97例UM患者作为研究对象,应用随机数字表法将其分成对照组(n=48)、观察组(n=49)。对照组使用达那唑治疗,观察组在此基础上加用加味桂枝茯苓丸治疗,两组均治疗3个月经周期。比较两组临床疗效、治疗前后肌瘤体积、血清性激素、转化生长因子(TGF)-β1、血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP)-9水平,以及治疗期间不良反应发生情况。结果治疗3个月经周期后,观察组总有效率(93.88%)高于对照组(79.17%)(P<0.05);两组肌瘤体积均较治疗前缩小,且观察组肌瘤体积小于对照组(均P<0.05);两组血清促卵泡激素、雌二醇、黄体生成素、TGF-β1、VEGF、MMP-9水平均较治疗前下降,且观察组上述指标水平均低于对照组(均P<0.05)。治疗期间,两组不良反应总发生率差异无统计学意义(P>0.05)。结论加味桂枝茯苓丸联合达那唑治疗UM的疗效确切,可缩小肌瘤体积,调节性激素分泌,降低血清TGF-β1、VEGF、MMP-9水平,且安全性良好。Objective To investigate the effects of modified Guizhi Fuling Pills combined with danazol on the myoma volume and the sex hormone levels in patients with uterine myoma(UM).Methods A total of 97 UM patients were selected as the study subjects and were divided into a control group(n=48)or an observation group(n=49)by the random number table method.The control group was treated with danazol,based on which the observation group was treated with modified Guizhi Fuling Pills additionally,and both groups were treated for 3 menstrual cycles.The clinical efficacy;myoma volume and serum levels of sex hormones,transforming growth factor(TGF)-β1,vascular endothelial growth factor(VEGF),and matrix metalloproteinase(MMP)-9 before and after treatment;and adverse reactions during treatment were compared between the two groups.Results After being treated for 3 menstrual cycles,the total effective rate of the observation group(93.88%)was higher than that of the control group(79.17%)(P<0.05);the myoma volumes in both groups were smaller than those before treatment,and the myoma volume was smaller in the observation group than in the control group's(all P<0.05);the serum levels of follicle-stimulating hormone,estradiol,luteinizing hormone,TGF-β1,VEGF,and MMP-9 in the two groups were lower than those before treatment,and the levels of the abovementioned indicators in the observation group were lower than those in the control group(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Modified Guizhi Fuling Pills combined with danazol has a definite effect in the treatment of UM,which can shrink the myoma volume,regulate the secretion of sex hormones,and lower the serum levels of TGF-β1,VEGF,and MMP-9,with good safety.

关 键 词：子宫肌瘤 加味桂枝茯苓丸 达那唑 性激素 肌瘤体积 转化生长因子 血管内皮生长因子 基质金属蛋白酶 

分 类 号：R737.33[医药卫生—肿瘤]