皮肤鳞状细胞癌转移机制的研究进展  

Metastatic mechanisms of cutaneous squamous cell carcinoma

作　　者：朱萍[1] 王大光[1] Zhu Ping;Wang Daguang(Department of Dermatology and Venereology,the First Affiliated Hospital with Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院皮肤性病科,南京210029

出　　处：《中华皮肤科杂志》2025年第2期186-189,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81000703、81472896);江苏省自然科学基金(BK2009437);江苏省六大人才高峰C类资助项目(2015-WSW-026)。

摘　　要：皮肤鳞状细胞癌(cSCC)是第二大常见的皮肤肿瘤,一旦转移,则预后不良。影响cSCC转移的因素包括:原发病灶直径、解剖部位、免疫抑制、临床类型、肿瘤浸润深度、分化程度和对血管、神经、淋巴管的浸润。Wnt/β连环蛋白、转化生长因子β和磷脂酰肌醇3-激酶/蛋白激酶B/哺乳类动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)等多条细胞内信号转导通路驱动肿瘤转移。本文综述cSCC转移的影响因素,以及上述信号通路在皮肤鳞状细胞癌转移机制中的作用,为转移性皮肤鳞状细胞癌的治疗提供新思路。Cutaneous squamous cell carcinoma(cSCC)is the second most common skin tumor,and metastatic cSCC usually has a poor prognosis.Many factors influence the metastasis of cSCC,including primary lesion diameter,anatomical location,immunosuppression,clinical types,depth of tumor invasion,degree of differentiation,and vascular,perineural,and lymphatic invasion.Multiple intracellular signaling pathways drive tumor metastasis,such as Wnt/β-catenin,transforming growth factorβ,and the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway.This review discusses the factors influencing cSCC metastasis and the role of the above signaling pathways in the metastatic mechanisms of cSCC,providing new insights for the treatment of metastatic cSCC.

关 键 词：肿瘤 鳞状细胞 肿瘤转移 免疫抑制 影响因素 信号转导 分子通路 

分 类 号：R739.5[医药卫生—肿瘤]