有机化学教学中常见的立体化学及应用  

Stereochemistry and Its Application in Organic Chemistry Teaching

作　　者：陈金珠[1] 郑燕玲[2] 张骥 彭大勇[1] 聂旭亮[1] CHEN Jinzhu;ZHENG Yanling;ZHANG Ji;PENG Dayong;NIE Xuliang(College of Chemistry and Materials,Jiangxi Agricultural University,Nanchang Jiangxi 330045,China;Nanchang Institute of Technology,Nanchang Jiangxi 330044,China;College of Forestry,Jiangxi Agricultural University,Nanchang Jiangxi 330045,China)

机构地区：[1]江西农业大学化学与材料学院,江西南昌330045 [2]南昌理工学院,江西南昌330044 [3]江西农业大学林学院,江西南昌330045

出　　处：《江西化工》2025年第1期114-117,共4页Jiangxi Chemical Industry

基　　金：国家自然科学基金地区项目(32160660);教育部协同育人项目(230800234154819);江西省高等学校教学改革研究重点课题(JXJG-22-3-5)。

摘　　要：有机化学是高等院校化学化工类专业的四大主干课程之一,也是有机合成化学、天然产物化学、药物化学等专业课程的基础性课程,而立体化学是该课程的教学重点和难点之一。学生们在学习立体化学时,往往缺乏空间立体感和想象力,存在一定的学习困难。为了使学生们在学习过程中更容易理解和掌握该部分内容,本文将从长期应用化学专业的有机化学及相关课程的教学与实践出发,着重对加成反应、消除反应、氧化反应、还原反应、取代反应、重排反应等反应类型中的立体化学现象进行阐述、归纳和总结,并通过实际的案例分析,对有机化学中立体化学现象在合成路线设计中的应用进行初步探讨,从而激发学生的学习兴趣,使学生理解和掌握反应中的立体化学问题。Organic Chemistry is one of the four main courses for chemistry and chemical engineering majors in higher education institutions.It serves as a foundational course for specialized courses such as Organic Synthetic Chemistry,Natural Product Chemistry and Medicinal Chemistry.Stereochemistry is one of the most challenging parts of this course.Students often struggle with spatial perception and imagination when learning stereochemistry,which leads to certain learning difficulties.To enhance students’understanding and mastery of this content during their learning process,based on long-term teaching and practical experience in Organic Chemistry and related courses for the Applied Chemistry major,focuses on elaborating,summarizing,and generalizing stereochemical phenomena in reaction types such as addition reactions,elimination reactions,oxidation reactions,reduction reactions,substitution reactions,and rearrangement reactions.Through actual case analyses,the application of stereochemical phenomena in Organic Chemistry in the design of synthetic routes is preliminarily explored.This is conducive to stimulating students’interest in learning and helping them understand and master stereochemical issues in reactions.

关 键 词：反式共平面 顺式共平面 构型翻转 立体化学 

分 类 号：G642[文化科学—高等教育学] O62[文化科学—教育学]