水环境中G蛋白偶联受体药物的污染及生态毒性研究进展  

Research progress of pollution and ecotoxicity of G protein-coupled receptor-acting pharmaceuticals in aquatic environment

作　　者：刘瑞鹏 张晗 LIU Ruipeng;ZHANG Han(School of Environmental Science and Technology,Dalian University of Technology,Dalian 116081)

机构地区：[1]大连理工大学环境学院,辽宁大连116081

出　　处：《高校化学工程学报》2025年第1期1-14,共14页Journal of Chemical Engineering of Chinese Universities

基　　金：国家自然科学基金(22106018);国家重点研发计划(2022YFC3902104)。

摘　　要：随着化学分析技术的进步,药物等微量污染物中潜在的环境风险逐渐被人们关注。G蛋白偶联受体(GPCR)药物约有700种,是40%药物的靶点,使用量巨大。污水中的GPCR药物由于无法被污水厂完全去除,最终流入水环境造成污染,对水生生物产生潜在危害。但目前仅有少数GPCR药物被检测,且其对水生生物产生的生态风险研究有限。文中对近年来GPCR药物相关研究进行了分析,总结了其主要来源及迁移转化、环境中GPCR药物分析检测方法、污染现状和生态毒性,并对今后的研究进行了展望。The increasing attention to micropollutants including pharmaceuticals in the environment is driven by advancements in analytical techniques and the potential environmental risks.G protein-coupled receptor(GPCR)account for 40%of pharmaceutical targets.There are around 700 GPCR-acting pharmaceuticals with large consumptions.Wastewater treatment plants are unable to completely remove GPCR-acting pharmaceuticals from sewage,which leads to their eventual release into aquatic environment and posing potential risks to aquatic organisms.However,only limited GPCR-acting pharmaceuticals are investigated in the aquatic environment,and their ecological risks to aquatic organisms remain largely unknown.This review provides a summary of recent studies on GPCR-acting pharmaceuticals,analyzing their main sources,migration and transformation,methods for analysis and detection of GPCR-acting pharmaceuticals in the environment,pollution and ecotoxicity,and offers prospects for future research.

关 键 词：G蛋白偶联受体药物 水环境 迁移转化 污染 生态毒性 

分 类 号：X131.2[环境科学与工程—环境科学]