星形胶质细胞连接蛋白43在癫痫中的研究进展  

Research advances of connexin 43 in astrocytes in epilepsy

作　　者：冯兰兰 高学军[3] 马磊 FENG Lan-lan;GAO Xue-jun;MA Lei(Medical College of Yan'an University,Yan'an 716000,China;Department of Neurology,The First Affiliated Hospital of Air Force Medical University,Xi'an 710032,China;Department of Neurology,The Affiliated Hospital of Yan'an University,Yan'an 716000,China)

机构地区：[1]延安大学医学院,陕西延安716000 [2]空军军医大学第一附属医院神经内科,西安710032 [3]延安大学附属医院神经内科,陕西延安716000

出　　处：《中国临床神经外科杂志》2024年第11期690-695,共6页Chinese Journal of Clinical Neurosurgery

基　　金：国家自然科学基金(82071449)。

摘　　要：连接蛋白43(CX43)是一种广泛表达的跨膜蛋白,通过缝隙连接(GJCs)和半通道(HCs)两种方式参与中枢神经系统的功能调节,使星形胶质细胞和神经元之间形成功能和代谢的偶联。GJCs主要介导细胞间的通讯,HCs介导胞内与胞外的物质交换。无论是癫痫病人致痫灶组织切片,还是癫痫动物模型组织切片,星形胶质细胞CX43的表达和功能偶联都发生改变。GJCs减少和HCs过度激活在癫痫的发生、同步和维持中发挥重要作用。癫痫动物模型研究发现,星形胶质细胞CX43的阻断剂可改善癫痫发作。这提示星形胶质细胞CX43可能是控制癫痫发作的一个新的治疗靶点。本文主要对星形胶质细胞CX43在癫痫中作用展开综述。Connexin 43(CX43),a transmembrane protein ubiquitously present in the central nervous system,participates in the functional and metabolic coupling between neurons and astrocytes via two pathways,namely gap junction channels(GJCs)and hemichannels(HCs).GJCs primarily account for direct intercellular communication,while HCs mediate the exchange of substances between the intracellular and extracellular milieus.Research indicates that in tissue sections of epileptic foci from patients with epilepsy and in animal models of epilepsy,both the expression pattern and functional coupling of CX43 have undergone marked alterations.Specifically manifested as a reduction in the quantity of GJCs and excessive activation of HCs,these changes play a crucial role in the genesis,development,and perpetuation of epilepsy.Further studies have revealed that the application of CX43 blockers can effectively ameliorate the symptoms of epileptic seizures,suggesting that CX43 might be a potential therapeutic target for controlling epileptic seizures.This article aims to review the role of CX43 in astrocytes in the pathological mechanism of epilepsy and its potential as a therapeutic target.

关 键 词：癫痫 星形胶质细胞 连接蛋白43 缝隙连接 半通道 

分 类 号：R742.1[医药卫生—神经病学与精神病学]