生物碱类化合物调控慢性肝病的作用及其机制  

Role of alkaloid compounds in regulating chronic liver diseases

作　　者：郑伊惠 王佳慧 赵铁建 段雪琳 汪磊[1] 郑洋 杨仕权 ZHENG Yihui;WANG Jiahui;ZHAO Tiejian;DUAN Xuelin;WANG Lei;ZHENG Yang;YANG Shiquan(Department of Medicine,Faculty of Chinese Medicine Science,Guangxi University of Chinese Medicine,Nanning 530222,China;School of Zhuang Medicine,Guangxi University of Chinese Medicine,Nanning 530222,China)

机构地区：[1]广西中医药大学赛恩斯新医药学院医学系,南宁530222 [2]广西中医药大学壮医药学院,南宁530222

出　　处：《临床肝胆病杂志》2025年第2期375-382,共8页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(82204755);广西壮瑶药重点实验室基金资助项目(GXZYYKF2023-05);广西自然科学基金项目(2023GXNSFBA026274,2024GXNSFAA010235)。

摘　　要：慢性肝病的常见原因包括病毒感染、乙醇滥用和自身免疫性疾病等。生物碱类化合物作为一类来源于植物的化合物,在调控慢性肝病方面展现出了重要潜力。近年来研究表明,生物碱类化合物能够通过多种途径发挥对慢性肝病的治疗作用。这些化合物对肝纤维化、炎症反应、氧化应激和细胞凋亡等关键病理过程具有调节作用,还通过调控多个信号通路来调节肝细胞代谢稳态,起到了调控慢性肝病的作用。本文对生物碱类化合物在慢性肝病治疗中的作用及其机制进行了综述,为慢性肝病治疗提供了新的思路和方向。Chronic liver diseases with common causes including viral infections,alcohol abuse,and autoimmune diseases.Alkaloids,as a class of plant-derived compounds,have shown significant potential in regulating chronic liver diseases.Recent studies have shown that alkaloids are able to exert a therapeutic effect on chronic liver diseases through multiple pathways.These compounds have a regulatory effect on key pathological processes such as liver fibrosis,inflammatory response,oxidative stress,and cell apoptosis,and they also regulate the metabolic homeostasis of hepatocytes by modulating multiple signaling pathways,thereby playing a role in regulating chronic liver diseases.This article reviews the role and mechanism of alkaloids in the treatment of chronic liver diseases,in order to provide new ideas and directions for the treatment of chronic liver diseases.

关 键 词：生物碱类 肝疾病 信号通路 

分 类 号：R575[医药卫生—消化系统]