自噬在对乙酰氨基酚诱导肝损伤中的作用  

Role of autophagy in treatment of paracetamol-induced liver injury

作　　者：邢国静 王丽菲 罗龙龙 郑晓凤[4] 高春 于晓辉 张久聪 XING Guojing;WANG Lifei;LUO Longlong;ZHENG Xiaofeng;GAO Chun;YU Xiaohui;ZHANG Jiucong(Department of Gastroenterology,The 940 Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China;Gansu Provincial Key Laboratory of Stem Cells and Genetic Drugs,The 940 Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China;Department of Gastroenterology,General Hospital of Ningxia Medical University,Yinchuan 750001,China;Department of Gastroenterology,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050 [2]中国人民解放军联勤保障部队第九四〇医院甘肃省干细胞与基因药物重点实验室,兰州730050 [3]宁夏医科大学总医院消化内科,银川750001 [4]兰州大学第二医院消化内科,兰州730030

出　　处：《临床肝胆病杂志》2025年第2期389-394,共6页Journal of Clinical Hepatology

基　　金：甘肃省卫生健康行业科研项目(GSWSKY2023-34);第九四〇医院研究生导师专项课题(2023YXKY020);中央高校优秀青年团队培育项目(31920220065);甘肃省非感染性肝病临床医学研究中心(21JR7RA017)。

摘　　要：对乙酰氨基酚(APAP)是临床上常用的解热镇痛药,过量服用则会造成严重肝损伤甚至死亡。近年来,APAP诱导的肝损伤(AILI)发生率呈上升趋势,已成为全球肝移植的第二大常见原因。自噬是一种高度保守的分解代谢过程,通过溶酶体降解去除不需要的胞质蛋白和细胞器,以实现细胞本身的代谢需要和细胞器的更新。大量研究表明,自噬在AILI的病理生理中起着关键作用,其机制涉及APAP蛋白加合物、氧化应激、JNK活化、线粒体功能障碍、炎症反应和细胞凋亡等。本文通过阐述自噬在AILI中的生物学机制,为AILI的治疗和自噬调节剂的开发提供理论依据。N-acetyl-p-aminophenol(APAP)is an antipyretic analgesic commonly used in clinical practice,and APAP overdose can cause severe liver injury and even death.In recent years,the incidence rate of APAP-induced liver injury(AILI)tends to increase,and it has become the second most common cause of liver transplantation worldwide.Autophagy is a highly conserved catabolic process that removes unwanted cytosolic proteins and organelles through lysosomal degradation to achieve the metabolic needs of cells themselves and the renewal of organelles.A large number of studies have shown that autophagy plays a key role in the pathophysiology of AILI,involving the mechanisms such as APAP protein conjugates,oxidative stress,JNK activation,mitochondrial dysfunction,inflammatory response and apoptosis.This article elaborates on the biological mechanism of autophagy in AILI,in order to provide a theoretical basis for the treatment of AILI and the development of autophagy regulators.

关 键 词：自噬 醋氨酚 化学性与药物性肝损伤 病理过程 

分 类 号：R96[医药卫生—药理学]