Causal Associations between Particulate Matter 2.5(PM_(2.5)),PM_(2.5) Absorbance,and Inflammatory Bowel Disease Risk:Evidence from a Two-Sample Mendelian Randomization Study  

作　　者：Xu Zhang Zhimeng Wu Lu Zhang Binglong Xin Xiangrui Wang Xinlan Lu Guifang Lu Mudan Ren Shuixiang He Yarui Li 

机构地区：[1]Department of Gastroenterology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi,China [2]Shannxi clinical research center of digestive disease(cancer division),Xi’an 710061,Shaanxi,China [3]Health Science Center,Xi’an Jiaotong University,Xi’an 710061,Shaanxi,China [4]Department of Urology,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200001,China [5]State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Shanghai 200001,China [6]Shanxi Institute of Science and Technology,Jincheng 048011,Shanxi,China

出　　处：《Biomedical and Environmental Sciences》2025年第2期167-177,共11页生物医学与环境科学(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.82303169);the Key Research and Development Program of Shaanxi(No.2021ZDLSF02-06).

摘　　要：Objective Several epidemiological observational studies have related particulate matter(PM)exposure to Inflammatory bowel disease(IBD),but many confounding factors make it difficult to draw causal links from observational studies.The objective of this study was to explore the causal association between PM_(2.5)exposure,its absorbance,and IBD.Methods We assessed the association of PM_(2.5)and PM_(2.5)absorbance with the two primary forms of IBD(Crohn’s disease[CD]and ulcerative colitis[UC])using Mendelian randomization(MR)to explore the causal relationship.We conducted two-sample MR analyses with aggregated data from the UK Biobank genome-wide association study.Single-nucleotide polymorphisms linked with PM_(2.5)concentrations or their absorbance were used as instrumental variables(IVs).We used inverse variance weighting(IVW)as the primary analytical approach and four other standard methods as supplementary analyses for quality control.Results The results of MR demonstrated that PM_(2.5)had an adverse influence on UC risk(odds ratio[OR]=1.010;95%confidence interval[CI]=1.001–1.019,P=0.020).Meanwhile,the results of IVW showed that PM_(2.5)absorbance was also causally associated with UC(OR=1.012;95%CI=1.004–1.019,P=0.002).We observed no causal relationship between PM_(2.5),PM_(2.5)absorbance,and CD.The results of sensitivity analysis indicated the absence of heterogeneity or pleiotropy,ensuring the reliability of MR results.Conclusion Based on two-sample MR analyses,there are potential positive causal relationships between PM_(2.5),PM_(2.5)absorbance,and UC.

关 键 词：Particulate matter 2.5 Inflammatory bowel disease Mendelian randomization 

分 类 号：R574[医药卫生—消化系统] X513[医药卫生—内科学]