Monotropein Alleviates Sepsis-induced Spleen Injury by Inhibiting the NF-κB/NLRP3 Axis and Activating the Nrf2 Pathway  

作　　者：Le Bian Feibiao Wang Yue Yang Kunmei Xie Tingzhaoyun Hu Jiadai Tang Lei Wang Zibo Dong 

机构地区：[1]Jiangsu Marine Pharmaceutical Resources Development Engineering Research Center,Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening,College of Pharmacy,Jiangsu Ocean University,Lianyungang 222005,Jiangsu,China [2]Central Laboratory,The Affiliated Lianyungang Hospital of Xuzhou Medical University(The First People’s Hospital of Lianyungang),Lianyungang 222000,Jiangsu,China

出　　处：《Biomedical and Environmental Sciences》2025年第2期270-276,共7页生物医学与环境科学(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.81773968);Priority Academic Program Development of Jiangsu Higher Education Institutions of China。

摘　　要：Sepsis is an inflammatory disease resulting from a dysregulated host response to infection that may lead to multiple organ failure and is commonly observed in patients with severe trauma or infectious diseases.Sepsis has become a major global public health issue due to its high incidence and fatality.It not only causes an excessive inflammatory response,but also leads to immune system dysfunction[1].

关 键 词：SEPSIS NRF2 TRAUMA 

分 类 号：R459.7[医药卫生—急诊医学]