内源性白介素-2转录调控机制的研究进展  

Research progress on the transcriptional regulation mechanisms of endogenous interleukin-2

作　　者：张艺唯 赵海苹 Zhang Yiwei;Zhao Haiping(Institute of Cerebrovascular Disease Research,Xuanwu Hospital of Capital Medical University,Beijing Geriatric Medical Research Center,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院脑血管病研究室、北京市老年病医疗研究中心,北京100053

出　　处：《中华脑血管病杂志(电子版)》2024年第6期595-600,共6页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

基　　金：国家自然科学基金项目(82271309,82071314)。

摘　　要：白介素-2(IL-2)是第一个被成功克隆的多细胞来源、具有多功能的细胞因子。IL-2主要由CD4+T细胞产生,对多种淋巴细胞具有重要的调节作用,因此在治疗免疫相关疾病中有广泛的应用前景。内源性IL-2的转录调控涉及多种顺式作用元件和反式作用因子,其中IL-2基因的启动子起着至关重要的作用。本文总结工程化IL-2的研究进展及IL-2基因的表达分布、表达方式、表观遗传修饰和启动子及与之结合的多种反式作用因子调控IL-2转录的分子机制,这对于未来优化IL-2治疗方案以及开发对靶标细胞选择性更高、半衰期更长、稳定性更好、副作用和免疫原性更小及治疗应用范围更大的新型免疫疗法具有重要意义。Interleukin-2(IL-2),the first successfully cloned cytokine derived from multicellular sources,is a multifunctional molecule primarily produced by CD4+T cells.It plays a crucial regulatory role in multiple lymphocyte lineages,making it a promising therapeutic option for immune-mediated diseases.The transcriptional regulation of endogenous IL-2 involves various cis-acting elements and trans-acting factors,with the IL-2 gene promoter playing a vital role.This paper reviews the latest developments in engineered IL-2 research,and explores the molecular mechanisms regulating IL-2 transcription.It covers the expression distribution,expression patterns,epigenetic modifications of the IL-2 gene,and the diverse trans-acting factors that interact with its promoter.These insights are vital for optimizing IL-2-based therapeutic strategies and developing novel immunotherapies with higher target cell selectivity,extended half-life,enhanced stability,minimized side effects and immunogenicity,and expanded therapeutic applications.

关 键 词：白介素-2 顺式作用元件 反式作用因子 转录调控 

分 类 号：R741[医药卫生—神经病学与精神病学]