恶性肿瘤相关出血性卒中的研究进展  

Research advances on malignancy related hemorrhagic stroke

作　　者：黄华[1] 梁志坚[1] Huang Hua;Liang Zhijian(Department of Neurology,the First Affiliated Hospital Of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院神经内科,南宁530021

出　　处：《中华脑血管病杂志(电子版)》2024年第6期611-615,共5页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

基　　金：中南地区(广西)慢病防控科技综合示范研究(2018YFC1311305)。

摘　　要：恶性肿瘤患者发生出血性卒中的风险显著高于正常人群,其风险随着肿瘤的进展而增加,提示恶性肿瘤可能直接或间接地导致出血性卒中的发生。近期研究发现,恶性肿瘤合并出血性卒中的患者,大多无传统的脑卒中危险因素,其出血性卒中的发生可能与恶性肿瘤有关,被称为恶性肿瘤相关出血性卒中。更值得关注的是,恶性肿瘤相关出血性卒中好发于颅脑恶性肿瘤或凝血功能障碍的患者,发生机制可能与肿瘤内出血、凝血功能异常有关。本文将对恶性肿瘤相关出血性卒中的研究进展做一综述。Patients with malignancy exhibit a significantly elevated risk of hemorrhagic stroke compared to the general population,with this risk escalating as the malignancy progresses.This suggests that malignancy may contribute directly or indirectly to the genesis of hemorrhagic stroke.Recently,a series of studies found that many patients with malignancy who suffer from hemorrhagic stroke lack traditional stroke risk factors,implying a potential direct or indirect link between malignancy and hemorrhagic stroke,termed as malignancy-related hemorrhagic stroke.Importantly,malignancy-related hemorrhagic stroke mainly occurs in patients with brain tumors and coagulopathy,with its pathogenesis potentially involving intratumoral hemorrhage and coagulation abnormalities.The aim of this review is to provide a summary of research advances on malignancy-related hemorrhagic stroke.

关 键 词：恶性肿瘤 出血性卒中 临床特点 发病机制 

分 类 号：R743.34[医药卫生—神经病学与精神病学]