视频眼震电图扫视检查对帕金森病轻度认知障碍患者的诊断价值  

Diagnostic Value of Video Nystagmography in Patients with Mild Cognitive Impairment in Parkinson′s Disease

作　　者：胡晓丹[1] 蒙云[1] 吕思娆 宁茜 HU Xiaodan;MENG Yun;LYU Sirao;NING Qian(Department of Neurology,Yulin Red Cross Hospital,Yulin 537000,Jiangxi,China)

机构地区：[1]玉林市红十字会医院神经内科,广西玉林537000

出　　处：《医学信息》2025年第3期85-90,共6页Journal of Medical Information

基　　金：玉林市科学研究与技术开发计划项目(编号:玉市科202324064)。

摘　　要：目的分析视频眼震电图扫视检查诊断帕金森病轻度认知障碍的价值。方法选取我院2021年2月-2023年12月收治的帕金森病患者60例,按照患者是否存在轻度认知障碍将其分成认知障碍组(n=30)与无认知障碍组(n=30),另外选取同期在我院接受体检的30例健康体检者,将其设为对照组;全部研究对象均接受视频眼震电图扫视检查,对检查结果进行分析比较,如扫视潜伏期、速度以及准确度。所有受试者均进行帕金森病认知功能评定量表(PD-CRS)、蒙特利尔认知评估量表(MoCA)评估,记录各项评分结果。多因素Logistic回归分析帕金森病轻度认知障碍的相关影响因素,并通过ROC分析对各指标单独诊断及联合诊断帕金森病轻度认知障碍的效能进行分析。结果认知障碍组、无认知障碍组扫视潜伏期均长于对照组(P<0.05),且认知障碍组扫视潜伏期长于无认知障碍组(P<0.05);认知障碍组、无认知障碍组扫视速度均低于对照组(P<0.05),且认知障碍组扫视速度低于无认知障碍组(P<0.05);认知障碍组、无认知障碍组的扫视准确度低于对照组(P<0.05),且认知障碍组扫视准确度低于无认知障碍组(P<0.05);认知障碍组、无认知障碍组MoCA、PD-CRS评分均低于对照组(P<0.05),且认知障碍组MoCA、PD-CRS评分均低于无认知障碍组(P<0.05)。多因素Logistic回归分析显示,扫视潜伏期延长、扫视速度缩短、扫视准确度下降与帕金森病轻度认知障碍的发生密切相关(P<0.05)。各指标联合预测帕金森病轻度认知障碍的AUC最大,联合AUC与扫视潜伏、扫视速度、扫视准确度、MoCA评分、PD-CRS评分比较,差异有统计学意义(P<0.05)。结论帕金森病轻度认知障碍患者存在明显的眼球扫视运动障碍,视频眼震电图扫视检查不仅具有较高的可操作性,而且简单无创,通过视频眼震电图扫视检查联合PD-CRS、MoCA量表的联合诊断模型能对帕金森病轻度认知�Objective To analyze the value of video nystagmography in the diagnosis of mild cognitive impairment in Parkinson′s disease.Methods A total of 60 patients with Parkinson′s disease admitted to our hospital from February 2021 to December 2023 were selected.According to whether the patients had mild cognitive impairment,they were divided into cognitive impairment group(n=30)and non-cognitive impairment group(n=30).In addition,30 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group.All subjects were examined by video nystagmography,and the results were analyzed and compared,such as saccade latency,speed and accuracy.All subjects were assessed with Parkinson′s disease cognitive function rating scale(PD-CRS)and Montreal cognitive assessment scale(MoCA),and the scores were recorded.Multivariate Logistic regression analysis was used to analyze the related influencing factors of mild cognitive impairment in Parkinson′s disease,and ROC analysis was used to analyze the efficacy of individual diagnosis and combined diagnosis of mild cognitive impairment in Parkinson's disease.Results The saccade latency of the cognitive impairment group and the non-cognitive impairment group was longer than that of the control group(P<0.05),and the saccade latency of the cognitive impairment group was longer than that of the non-cognitive impairment group(P<0.05).The saccade speed of the cognitive impairment group and the non-cognitive impairment group was lower than that of the control group(P<0.05),and the saccade speed of the cognitive impairment group was lower than that of the non-cognitive impairment group(P<0.05).The saccade accuracy of the cognitive impairment group and the non-cognitive impairment group was lower than that of the control group(P<0.05),and the saccade accuracy of the cognitive impairment group was lower than that of the non-cognitive impairment group(P<0.05).The MoCA and PD-CRS scores of the cognitive impairment group and the non-cogniti

关 键 词：视频眼震电图 扫视检查 帕金森病 轻度认知障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学]