肿瘤标志物CEA、CA-199联合检测在消化道肿瘤诊断中的应用价值  

Application Value of Combined Detection of Tumor Markers CEA and CA-199 in the Diagnosis of Digestive Tract Tumors

作　　者：匡重英 KUANG Chongying(Department of Clinical Laboratory,Taihe County People′s Hospital,Taihe 343700,Jiangxi,China)

机构地区：[1]泰和县人民医院检验科,江西泰和343700

出　　处：《医学信息》2025年第3期138-140,144,共4页Journal of Medical Information

摘　　要：目的探讨肿瘤标志物CEA、CA-199联合检测在消化道肿瘤诊断中的应用价值。方法选取2020年1月-2023年12月泰和县人民医院收治的60例消化道肿瘤患者为恶性组,选择同期60例消化道良性病变患者作为良性组,健康体检者60例作为对照组。通过胃肠镜检查判断有无胃肠道肿瘤,分别检测CEA、CA-199比较各组诊断情况。结果恶性组CEA、CA-199水平高于良性组及对照组,良性组CEA、CA-199水平高于对照组,差异有统计学意义(P<0.05)。恶性组CEA、CA-199阳性检测率高于良性组(P<0.05)。以手术病例活检为金标准,CEA、CA-199联合检测的诊断效能优于两项肿瘤标志物单一检测(P<0.05)。结论肿瘤标志物CEA、CA-199联合检测在消化道肿瘤诊断中的应用价值确切,能作为肿瘤良恶性鉴别标准,同时能够提高消化道肿瘤诊断敏感度。Objective To explore the application value of combined detection of tumor markers CEA and CA-199 in the diagnosis of digestive tract tumors.Methods Sixty patients with gastrointestinal tumors admitted to Taihe County People's Hospital from January 2020 to December 2023 were selected as the malignant group,60 patients with benign gastrointestinal lesions were selected as the benign group,and 60 healthy subjects were selected as the control group.The presence or absence of gastrointestinal tumors was determined by gastrointestinal endoscopy.CEA and CA-199 were detected respectively,and the diagnosis of each group was compared.Results The levels of CEA and CA-199 in the malignant group were higher than those in the benign group and the control group,and the levels of CEA and CA-199 in the benign group were higher than those in the control group,the differences were statistically significant(P<0.05).The positive detection rates of CEA and CA-199 in the malignant group were higher than those in the benign group(P<0.05).With the biopsy of surgical cases as the gold standard,the diagnostic efficacy of combined detection of CEA and CA-199 was better than that of single detection of two tumor markers(P<0.05).Conclusion The combined detection of tumor markers CEA and CA-199 has definite application value in the diagnosis of digestive tract tumors,which can be used as a standard for differentiating benign and malignant tumors,and can improve the diagnostic sensitivity of digestive tract tumors.

关 键 词：肿瘤标志物检测 消化道肿瘤 检测诊断 

分 类 号：R735[医药卫生—肿瘤]