2024年泌尿外科分子影像学研究回顾与未来展望  

Review and future prospects of molecular imaging in urology in 2024

作　　者：于天熙 王子琦 徐万海[1,3] Yu Tianxi;Wang Ziqi;Xu Wanhai(NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics/Heilongjiang Key Laboratory of Scientific Research in Urology,Harbin Medical University,Harbin 150001,China;Department of Urology,Harbin Medical University Cancer Hospital,Harbin 150001,China;Department of Urology,The 2nd Afiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学国家卫健委分子探针与靶向治疗重点实验室/黑龙江省泌尿外科基础医学重点实验室,哈尔滨150001 [2]哈尔滨医科大学附属肿瘤医院泌尿外科,哈尔滨150001 [3]哈尔滨医科大学附属第二医院泌尿外科,哈尔滨150001

出　　处：《泌尿外科杂志(电子版)》2025年第1期48-54,共7页Journal of Urology for Clinicians(Electronic Version)

摘　　要：光学分子影像学近年来发展迅速,在前列腺癌中,多种近红外荧光和纳米探针等在诊断、手术导航等方面颇具潜力;在肾癌中,自发荧光光谱、荧光探针有力推动肿瘤的诊疗进程;在膀胱癌中,各类探针显著提高肿瘤的可视化,精确识别肿瘤边界并增强成像敏感性。放射性核素正电子发射断层扫描(positron emission tomography,PET)成像方面也进展显著,在前列腺癌中,前列腺特异性膜抗原(prostate-specific membrane antigen,PSMA)PET/CT检测转移更敏感,在临床分期、决策、预后及治疗方面意义重大;在肾癌中,多种PET/CT成像各有特点,显著增强诊断效能;在膀胱癌方面,PET/CT在临床分期及治疗方面发挥重要作用。未来,随着分子影像学的不断进步,必将在泌尿疾病领域发挥更关键的作用,为疾病的精准诊疗持续赋能,推动泌尿疾病的诊治向更高水平迈进。Optical molecular imaging has made significant advancements in recent years.In prostate cancer,various near-infrared fluorescence and nanoprobe technologies show great potential in diagnosis and surgical navigation.In renal cancer,spontaneous fluorescence spectra and fluorescence probes have effectively advanced the diagnosis and treatment of tumors.In bladder cancer,various probes have substantially improved tumor visualization,enabled precise identification of tumor boundaries and enhanced imaging sensitivity.Positron emission tomography(PET)imaging has also made considerable progress.In prostate cancer,prostate-specific membrane antigen(PSMA)PET/CT has demonstrated greater sensitivity in detecting metastasis and holds significant clinical value in staging,decision-making,prognosis,and treatment.In renal cancer,various PET/CT imaging techniques offer distinct advantages,significantly enhancing diagnostic effectiveness.In bladder cancer,PET/CT plays a critical role in clinical staging and treatment.In future,with the development of molecular imaging,it is expected to play a more pivotal role in the field of urinary diseases,empowering precise diagnosis and treatment and promoting continuous progress in the diagnosis and treatment of urinary diseases.

关 键 词：光学分子影像学 分子探针 正电子发射断层扫描 放射性核素 泌尿系疾病 

分 类 号：R737.25[医药卫生—肿瘤]