基于文献分析探讨干眼症中医证型及证素分布特征  

Exploringthe distribution characteristics of TCM patterns and elements in dry eye disease based on literature analysis

作　　者：张海 冷祥杰 周婳 朱可吟 徐文萱 曾艳 路雪婧 Zhang Hai;Leng Xiangjie;Zhou Hua;Zhu Keyin;Xu Wenxuan;Zeng Yan;Lu Xuejing(Eye School of Chengdu University of TCM,Chengdu,Sichuan,610075;Chinese Medicine Postdoctoral Research Station of China Academy of Chinese Medical Sciences,Beijing,China,100700)

机构地区：[1]成都中医药大学眼科学院,四川成都610075 [2]中国中医科学院博士后科研流动站,北京100700

出　　处：《中医眼耳鼻喉杂志》2025年第1期7-10,共4页Journal of Chinese Ophthalmology and Otorhinolaryngology

基　　金：国家重点研发计划“中医药现代化”重点专项(2023YFC3503000)。

摘　　要：目的通过文献分析探究干眼(白涩症)在中医证候和证素方面的分布情况。方法本研究检索截至2024年1月中国期刊全文数据库、维普中文期刊全文数据库、万方数据知识服务云平台等数据库中所有符合标准的中医干眼临床研究。提取中医干眼临床研究的第一作者、发表年份及证型、证素等信息,利用Excel 2021建立干眼证型数据库,统计分析干眼症的证型和证素分布情况。结果本研究共纳入中医干眼临床研究213篇,共包括18030例干眼症患者,75种原始证型,经规范化处理后,仍剩余38种证型,经证型拆分后共获得6种病位证素及13种病性证素。纳入干眼患者总样本量超过500例的证型共6种,它们在中医干眼临床研究文献出现频率也最高,各证型总样本量及文献出现频率分别为肝肾阴虚证7206例(45.66%)、肺阴不足证2390例(19.63%)、气阴两虚证1897例(18.72%)、肝经郁热证1299例(8.68%)、脾胃湿热证895例(8.22%)、阴虚湿热769例(10.05%)。虚证、实证及虚实夹杂证之比约7∶2∶1。病位证素在文献中出现频率较高者包括:肝(44.00%)、肾(33.85%)、肺(16.00%)。病性证素在文献中出现频率较高者包括:阴虚(73.85%)、火(热)(26.46%)、气虚(13.85%)、湿(12.62%)、郁(9.85%)等。结论干眼主要证型为肝肾阴虚证、肺阴不足证、气阴两虚证、肝经郁热证、脾胃湿热证及阴虚湿热证。病位主要涉及肝、肾、肺,病性以阴虚为主。Objective Through literature analysis,explore the distribution of Traditional Chinese Medicine(TCM)patterns and Syndrome Elements of dry eye disease(DED).Methods This study searched all TCM clinical research studies on DED in Chinese full-text databases including China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform,and VIP Chinese Journal Database up to January 2024.Information such as the first author,publication year,syndrome types,and elements of TCM clinical research on dry eye was extracted.An Excel 2021 database of DED types was established to analyze the distribution of syndrome types and elements of DED.Results A total of 213 TCM clinical research studies on DED were included in this study,covering 18,030 cases and 75 original syndrome types.After standardization,38 syndrome types remained.After syndrome type breakdown,a total of 6 disease location elements and 13 disease nature elements were obtained.There were 6 syndrome types with a total sample size of over 500 cases,which had the highest frequency in TCM clinical research literature on dry eye.The total sample size and frequency of appearance of each syndrome type were as follows:Liver and Kidney Yin Deficiency Syndrome with 7,206 cases(45.66%),Lung Yin Deficiency Syndrome with 2,390 cases(19.63%),Qi and Yin Deficiency Syndrome with 1,897 cases(18.72%),Liver Qi Stagnation Heat Syndrome with 1,299 cases(8.68%),Spleen and Stomach Damp-Heat Syndrome with 895 cases(8.22%),Yin Deficiency Damp-Heat Syndrome with 769 cases(10.05%).The ratio of Deficiency Syndrome,Excess Syndrome,and Deficiency-Excess Mixed Syndrome is approximately 7∶2∶1.The disease location elements with high frequency in the literature include:Liver(44.00%),Kidney(33.85%),Lung(16.00%).The disease nature elements with high frequency in the literature include:Yin Deficiency(73.85%),Fire(Heat)(26.46%),Qi Deficiency(13.85%),Dampness(12.62%),Stagnation(9.85%),etc.Conclusion DED is complex with diverse syndrome types,with the main syndrome types being Liver

关 键 词：干眼 白涩症 证候 证素 

分 类 号：R77[医药卫生—眼科]