大豆分离蛋白修饰酸改性多壁碳纳米管负载酮洛芬特性研究  

Characteristics of Ketoprofen Loading on Soy Protein-Isolate-Modified Acid-Activated Multi-Walled Carbon Nanotubes

作　　者：牛瑞艳 于丹丹 徐静 莫光路 曹迪 Niu Ruiyan;Yu Dandan;Xu Jing;Mo Guanglu;Cao Di(College of Life Science and Biotechnology,Heilongjiang Bayi Agricultural University,Heilongjiang Provincial Key Laboratory of Environmental Microbiology and Recycling of Argo-Waste in Cold Region,Key Laboratory of Low-carbon Green Agriculture in Northeastern China,Ministry of Agriculture and Rural Affairs,Daqing 163319,China)

机构地区：[1]黑龙江八一农垦大学生命科学技术学院,黑龙江省寒区环境微生物与农业废弃物资源化利用重点实验室,农业农村部东北平原农业绿色低碳重点实验室,黑龙江大庆163319

出　　处：《黑龙江科学》2025年第4期22-26,共5页Heilongjiang Science

摘　　要：为提高酸改性多壁碳纳米管的负载酮洛芬能力,探究改性多壁碳纳米管是否存在缓释效果,以酸改性多壁碳纳米管的改性超声时间、改性的混酸体积比例和负载酮洛芬比例为条件,设置三水平三因素正交试验,找到最适负载条件,最适负载条件为酸改性体积比为浓硫酸∶浓硝酸=3∶1、超声时间30 min、载药比为碳纳米管∶酮洛芬=1∶2。用大豆分离蛋白对酸改性多壁碳纳米管进一步修饰,以提高其生物相容性。利用改性多壁碳纳米管负载酮洛芬并进行缓释实验,发现改性多壁碳纳米管对酮洛芬的缓释效果较好。To enhance the ketoprofen loading capacity of acid-modified multi-walled carbon nanotubes(MWCNTs)and assess their sustained-release potential,a three-level,three-factor orthogonal experiment is conducted,with variables including ultrasonic treatment time,the volume ratio of mixed acids for modification,and the ketoprofen loading ratio.The optimal conditions identified are a volume ratio of concentrated sulfuric acid to nitric acid of 3∶1,an ultrasonic treatment time of 30 minutes,and a loading ratio of MWCNTs to ketoprofen of 1∶2.To further enhance biocompatibility,the acid-modified MWCNTs are coated with soy protein isolate(SPI).The ketoprofen-loaded and modified MWCNTs exhibits a favorable sustained-release profile in experimental studies.

关 键 词：酸改性多壁碳纳米管 大豆分离蛋白 酮洛芬 体外缓释 

分 类 号：O613.7[理学—无机化学] TB383.1[理学—化学]