原发性开角型青光眼患者房水EPO、TGF-β_(1)水平与视盘RNFL厚度及视野MD程度的关系  

Relationship between EPO and TGF-β_(1)levels in aqueous humor and the thickness of optic disc RNFL and MD degree of visual field in patients with primary open-angle glaucoma

作　　者：刘琪[1] 买尔哈巴·玉素甫 丁琳[1] 麦迪娜·那毕江 谢小东[1] LIU Qi;Maierhaba·Yusufu;DING Lin;Maidina·Nabijiang;XIE Xiaodong(Department of Ophthalmology,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院眼科,新疆乌鲁木齐830001

出　　处：《检验医学与临床》2025年第5期577-580,586,共5页Laboratory Medicine and Clinic

基　　金：新疆维吾尔自治区自然科学基金面上项目(2022D01C134)。

摘　　要：目的探讨原发性开角型青光眼(POAG)患者房水促红细胞生成素(EPO)、转化生长因子β_(1)(TGF-β_(1))水平与视盘视网膜神经纤维层(RNFL)厚度及视野平均缺损(MD)程度的关系。方法选取2019年3月至2021年1月该院收治的50例(50眼)POAG患者作为研究组,根据不同视野MD程度将其分为A组(视野MD程度<-12 dB)、B组(视野MD程度-12~-6 dB)、C组(视野MD程度>-6 dB)。另选取同期该院收治的年龄相当的22例(22眼)白内障患者作为对照组。测量各组眼压、前房深度、眼轴和角膜中央厚度;测量并计算视野MD程度,测量视盘RNFL厚度。采集各组房水样本,采用酶联免疫吸附试验检测房水EPO、TGF-β_(1)水平。采用Pearson相关分析POAG患者房水EPO、TGF-β_(1)水平与视盘RNFL厚度及视野MD程度的相关性。结果A、B、C组房水EPO、TGF-β_(1)水平均明显高于对照组,视野MD程度及视盘RNFL厚度均明显低于对照组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,POAG患者房水样本EPO水平与视野MD程度及视盘RNFL厚度均呈负相关(r=-0.869、-0.803,P<0.05),TGF-β_(1)水平与视野MD程度及视盘RNFL厚度均呈负相关(r=-0.853、-0.902,P<0.05)。结论POAG患者房水EPO、TGF-β_(1)水平均高于白内障患者,且POAG患者EPO、TGF-β_(1)水平升高与视野MD程度及视盘RNFL厚度均存在一定关系。Objective To investigate the relationship between the levels of erythropoietin(EPO)and transforming growth factor-β_(1)(TGF-β_(1))in the aqueous humor of patients with primary open angle glaucoma(POAG)and the thickness of retinal nerve fiber layer(RNFL)and mean defect(MD)degree of visual field.Methods A total of 50 eyes of 50 POAG patients admitted to the hospital from March 2019 to January 2021 were selected as the study group.The patients were divided into group A(visual field MD degree<—12 dB),group B(visual field MD degree—12 to—6 dB),and group C(visual field MD degree>—6 dB)according to the visual field MD degree.Twenty-two age-matched cataract patients(22 eyes)from the hospital were selected as the control group.Intraocular pressure,anterior chamber depth,axial length and central corneal thickness were measured in each group.The MD degree was measured and the thickness of the optic disc RNFL was measured.The aqueous humor samples of each group were collected,and the levels of EPO and TGF-β_(1)in aqueous humor were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to analyze the correlation between the levels of EPO and TGF-β_(1)in the aqueous humor and the thickness of optic disc RNFL and MD degree of visual field in POAG patients.Results The levels of EPO and TGF-β_(1)in the aqueous humor of groups A,B,and C were significantly higher than those in the control group(P<0.05),and the MD degree and RNFL thickness of the optic disc were significantly lower than those in the control group(P<0.05).Pearson correlation analysis showed that EPO level in aqueous humor was negatively correlated with MD degree of visual field and optic disc RNFL thickness of optic disc in the study group(r=—0.869,—0.803,P<0.05).The level of TGF-β_(1)was negatively correlated with visual field MD degree and optic disc RNFL thickness(r=—0.853,—0.902,P<0.05).Conclusion The levels of EPO and TGF-β_(1)in the aqueous humor of POAG patients are higher than those of cataract patients,and

关 键 词：原发性开角型青光眼 促红细胞生成素 转化生长因子β_(1) 视网膜神经纤维层 视野平均缺损程度 

分 类 号：R775.2[医药卫生—眼科] R446.1[医药卫生—临床医学]