不可逆电穿孔治疗局限性前列腺癌的研究进展  

Irreversible electroporation for the treatment of prostate cancer:An update

作　　者：靳晓旭(综述) 赵晓东 许松(审校) JIN Xiao-xu;ZHAO Xiao-dong;XU Song(Department of Urology,Jinling Hospital Affiliated to Nanjing University School of Medicine,Nanjing,Jiangsu 210002,China;Department of Urology,General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China)

机构地区：[1]南京大学医学院附属金陵医院泌尿外科,江苏南京210002 [2]东部战区总医院泌尿外科,江苏南京210001

出　　处：《中华男科学杂志》2025年第1期76-80,共5页National Journal of Andrology

摘　　要：前列腺癌是全球男性泌尿生殖系统最常见的恶性肿瘤,我国前列腺癌发病率呈持续上涨趋势。对于局限性前列腺癌,根治性前列腺切除术或根治性放疗能取得很好的肿瘤控制效果,但并发症严重影响患者的生活质量。局灶治疗可将治疗集中在前列腺癌的主要病灶从而降低并发症的发生。不可逆电穿孔是一种新兴的局灶治疗方式,在尽可能彻底消融肿瘤的同时对尿道、直肠、神经血管束等重要结构不造成热损伤,为局限性前列腺癌患者提供了一个颇具前景的治疗选择。本文就不可逆电穿孔的最新研究进展进行综述。Prostate cancer(PCa)is globally the most prevalent malignancy in the male genitourinary system,with a continuously ascending incidence in China.For the treatment of localized PCa,radical prostatectomy and radiotherapy have demonstrated effective suppression of the tumor,but with obvious complications that markedly compromise the life quality of the patients.Focal therapy,by targeting the principal tumor foci,can largely reduce the incidence of complications.In this context,irreversible electroporation represents an emerging modality of focal treatment capable of ablating the tumor as thoroughly as possible while sparing such critical structures as the urethra,rectum and neurovascular bundles from thermal damage,and thus offers a promising option for the management of localized PCa.This article presents an overview of the latest advances in the studies of irreversible electroporation.

关 键 词：前列腺癌 不可逆电穿孔 纳米刀 局灶治疗 

分 类 号：R737.25[医药卫生—肿瘤]