硒的抗菌作用研究进展  

Research Advances on the Antimicrobial Effect of Selenium

作　　者：刘泉莹 李佳梦 白雅芝 张双庆 Liu Quan-ying;Li Jia-meng;Bai Ya-zhi;Zhang Shuang-qing(National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050)

机构地区：[1]中国疾病预防控制中心营养与健康所,北京100050

出　　处：《国外医药(抗生素分册)》2025年第1期1-5,共5页World Notes on Antibiotics

摘　　要：针对抗菌剂耐药性问题,有效解决方案是研发新型的高效且低副作用的抗菌剂。硒作为一种必需微量元素,具有抗氧化、抗炎和抗菌等生物活性。研究表明,硒的抗菌机制主要包括影响细胞内氧化还原状态、破坏细胞膜完整性以及对细胞遗传物质的作用等。目前硒及其衍生物在抗菌领域的研究仍在不断进行,未来有望开发出更广泛应用的抗菌剂。本综述将关于硒的抗菌机制及其作为抗菌剂的研究进展做简要总结,旨在为相关领域研究提供参考。An effective solution to the problem of antimicrobial resistance is the development of new antimicrobial agents with high efficiency and minimal adverse effects.An important trace element,selenium has several biological actions,such as anti-inflammatory,antibacterial,and antioxidant effects.It has been demonstrated that the antimicrobial mechanism of selenium primarily encompasses the modulation of the intracellular redox state,the disruption of the integrity of cell membranes,and the interaction with intracellular genetic material.Future discoveries in this sector are expected to result in the production of more extensively used antimicrobial agents.Research on the effects of selenium and its derivatives in the field of antimicrobial agents is still underway.This review briefly summarizes the research advances on the antimicrobial effects of selenium and its use as an antimicrobial agent,aiming to provide a reference for research in related fields.

关 键 词：硒 抗菌作用 抗菌机制 纳米粒子 氧化还原状态 

分 类 号：R978.19[医药卫生—药品] R151[医药卫生—药学]